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Tbio
LAMA3
Laminin subunit alpha-3

Protein Summary
Description
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes. The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313654
  • ENSP00000324532
  • ENSG00000053747

Symbol
  • LAMNA
  • E170
  • LOCS
  • BM600
  • LAMNA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
cell type or tissue
0.8
virus perturbation
0.79
histone modification site profile
0.77
small molecule perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.8   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.8   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (154)
SPINK4
Tdark
Family:  Enzyme
Novelty:  0.06706505
p_int:  0.999957569
p_ni:  0.000042431
Score:  0.188
Data Source:  BioPlex,STRINGDB
HYOU1
Tbio
Novelty:  0.00833649
p_int:  0.999839415
p_ni:  0.000160584
p_wrong:  1e-9
Data Source:  BioPlex
CD44
Tbio
Novelty:  0.00011321
p_int:  0.997936535
p_ni:  0.002063458
p_wrong:  7e-9
Score:  0.691
Data Source:  BioPlex,STRINGDB
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.993833373
p_ni:  0.006166624
p_wrong:  3e-9
Score:  0.157
Data Source:  BioPlex,STRINGDB
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.989086086
p_ni:  0.010913837
p_wrong:  7.7e-8
Data Source:  BioPlex
TSHR
Tclin
Family:  GPCR
Novelty:  0.00074972
p_int:  0.987295952
p_ni:  0.012676485
p_wrong:  0.000027563
Score:  0.247
Data Source:  BioPlex,STRINGDB
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.984310752
p_ni:  0.015689205
p_wrong:  4.4e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.983043546
p_ni:  0.016955679
p_wrong:  7.75e-7
Score:  0.151
Data Source:  BioPlex,STRINGDB
IL7R
Tbio
Novelty:  0.00107223
p_int:  0.980140647
p_ni:  0.019204929
p_wrong:  0.000654424
Data Source:  BioPlex
GML
Tdark
Novelty:  0.04982168
p_int:  0.971882939
p_ni:  0.027891587
p_wrong:  0.000225475
Data Source:  BioPlex
Pathways (38)
Anchoring fibril formation (R-HSA-2214320)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring fibril formation
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Collagen formation
Name
Explore in Pharos
Explore in Source
Anchoring fibril formation
Assembly of collagen fibrils and other multimeric structures
Cell junction organization
Cell-Cell communication
Collagen formation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
70.2
monocyte percentage of leukocytes
1
1
1
61
leukocyte count
1
1
1
46.9
reticulocyte count
2
1
2
30.2
ovarian serous carcinoma
1
1
0
1.2
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
70.2
monocyte percentage of leukocytes
1
61
leukocyte count
1
46.9
reticulocyte count
2
30.2
ovarian serous carcinoma
0
1.2
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
laminin subunit alpha 3
VGNC:5179
455339
Macaque
laminin subunit alpha 3
701313
Mouse
MGI:99909
16774
Dog
laminin subunit alpha 3
VGNC:42566
480173
Horse
laminin subunit alpha 3
791238
Species
Name
OMA
EggNOG
Inparanoid
Chimp
laminin subunit alpha 3
Macaque
laminin subunit alpha 3
Mouse
Dog
laminin subunit alpha 3
Horse
laminin subunit alpha 3
Publication Statistics
PubMed Score 135.80
PubMed score by year
PubTator Score 75.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title