You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

Protein Summary
Description
The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301202
  • ENSP00000301202
  • ENSG00000167618
  • ENST00000351841
  • ENSP00000301203
  • ENST00000612901
  • ENSP00000478193
  • ENSG00000274084
  • ENST00000620256
  • ENSP00000477747
  • ENST00000621280
  • ENSP00000480904
  • ENSG00000277335
  • ENST00000622556
  • ENSP00000477535

Symbol
  • CD306
  • CD306
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.52
cell type or tissue
0.52
tissue
0.46
small molecule perturbation
0.43
chemical
0.41


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.65   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.65   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
COL5A1
Tbio
Novelty:  0.00506815
p_int:  0.999999995
p_ni:  5e-9
Data Source:  BioPlex
COL12A1
Tbio
Novelty:  0.0239421
p_int:  0.99999999
p_ni:  9e-9
p_wrong:  1e-9
Data Source:  BioPlex
COL2A1
Tbio
Novelty:  0.0011102
p_int:  0.999999986
p_ni:  1.4e-8
p_wrong:  1e-9
Data Source:  BioPlex
COL5A2
Tbio
Novelty:  0.01352973
p_int:  0.99999993
p_wrong:  7e-8
Data Source:  BioPlex
COL3A1
Tbio
Novelty:  0.00197327
p_int:  0.999999927
p_ni:  7.3e-8
Data Source:  BioPlex
SCARA3
Tbio
Novelty:  0.00621523
p_int:  0.99999901
p_ni:  9.9e-7
Data Source:  BioPlex
COLEC12
Tbio
Novelty:  0.02882427
p_int:  0.999998731
p_ni:  0.000001269
Data Source:  BioPlex
COL4A6
Tbio
Novelty:  0.02524039
p_int:  0.999997546
p_ni:  0.000002092
p_wrong:  3.62e-7
Data Source:  BioPlex
COL4A1
Tbio
Novelty:  0.00358049
p_int:  0.999992999
p_ni:  0.000004838
p_wrong:  0.000002163
Data Source:  BioPlex
FN1
Tchem
Novelty:  0.00003647
p_int:  0.999982824
p_ni:  0.000017176
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
62.5
educational attainment
1
2
2
62.5
educational attainment
1
2
2
62.5
1
1
0
1.5
56.6
1
1
0
1.5
56.6
Items per page:
1 – 5 of 15
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
62.5
educational attainment
2
62.5
educational attainment
2
62.5
0
1.5
56.6
0
1.5
56.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 21.65
PubMed score by year
PubTator Score 15.62
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title