LAIR1
Leukocyte-associated immunoglobulin-like receptor 1
Protein Summary
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. The protein encoded by t ...more
- ENST00000348231
- ENSP00000301193
- ENSG00000167613
- ENST00000391742
- ENSP00000375622
- ENST00000474878
- ENSP00000418998
- ENST00000610549
- ENSP00000481204
- ENSG00000276053
- ENST00000614937
- ENSP00000479006
- ENSG00000278154
- ENST00000614946
- ENSP00000478853
- ENSG00000274110
- ENST00000616612
- ENSP00000479682
- ENST00000618434
- ENSP00000479133
- ENST00000619717
- ENSP00000479707
- ENST00000619817
- ENSP00000480619
- ENSG00000276163
- ENST00000620077
- ENSP00000482922
- ENST00000620357
- ENSP00000479649
- ENST00000620726
- ENSP00000478405
- ENST00000622097
- ENSP00000480659
- CD305
- CD305
- LAIR-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
phenotype | 0.77 | ||
virus perturbation | 0.76 | ||
tissue sample | 0.64 | ||
cell line | 0.61 | ||
kinase perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 119.35 (req: < 5)
Gene RIFs: 60 (req: <= 3)
Antibodies: 700 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 119.35 (req: >= 5)
Gene RIFs: 60 (req: > 3)
Antibodies: 700 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0