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Tbio
LAIR1
Leukocyte-associated immunoglobulin-like receptor 1

Protein Summary
Description
Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. The protein encoded by t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348231
  • ENSP00000301193
  • ENSG00000167613
  • ENST00000391742
  • ENSP00000375622
  • ENST00000474878
  • ENSP00000418998
  • ENST00000610549
  • ENSP00000481204
  • ENSG00000276053
  • ENST00000614937
  • ENSP00000479006
  • ENSG00000278154
  • ENST00000614946
  • ENSP00000478853
  • ENSG00000274110
  • ENST00000616612
  • ENSP00000479682
  • ENST00000618434
  • ENSP00000479133
  • ENST00000619717
  • ENSP00000479707
  • ENST00000619817
  • ENSP00000480619
  • ENSG00000276163
  • ENST00000620077
  • ENSP00000482922
  • ENST00000620357
  • ENSP00000479649
  • ENST00000620726
  • ENSP00000478405
  • ENST00000622097
  • ENSP00000480659

Symbol
  • CD305
  • CD305
  • LAIR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.77
virus perturbation
0.76
tissue sample
0.64
cell line
0.61
kinase perturbation
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.35   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 700   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.35   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 700   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
CD300A
Tbio
Novelty:  0.01745189
Score:  0.961
Data Source:  STRINGDB
CD33
Tclin
Novelty:  0.00074958
Score:  0.952
Data Source:  STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.941
Data Source:  STRINGDB
ITGAX
Tbio
Novelty:  0.00040471
Score:  0.939
Data Source:  STRINGDB
CD93
Tbio
Novelty:  0.01324003
Score:  0.937
Data Source:  STRINGDB
FCAR
Tbio
Novelty:  0.00436414
Score:  0.93
Data Source:  STRINGDB
ITGAL
Tclin
Novelty:  0.00099016
Score:  0.929
Data Source:  STRINGDB
CEACAM1
Tbio
Novelty:  0.0029954
Score:  0.929
Data Source:  STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.928
Data Source:  STRINGDB
CD53
Tbio
Novelty:  0.01722633
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (105)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
36
18
49
98.9
creatine kinase measurement
5
5
9
98.4
phosphatidylinositol measurement
54
35
249
96
alkaline phosphatase measurement
2
3
3
18.1
94.8
blood metabolite measurement
2
2
2
93.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
49
98.9
creatine kinase measurement
9
98.4
phosphatidylinositol measurement
249
96
alkaline phosphatase measurement
3
18.1
94.8
blood metabolite measurement
2
93.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leukocyte associated immunoglobulin like receptor 1
456283
Macaque
leukocyte associated immunoglobulin like receptor 1
695533
Mouse
MGI:105492
52855
Rat
RGD:1560048
574531
Dog
leukocyte associated immunoglobulin like receptor 1
484308
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leukocyte associated immunoglobulin like receptor 1
Macaque
leukocyte associated immunoglobulin like receptor 1
Mouse
Rat
Dog
leukocyte associated immunoglobulin like receptor 1
Publication Statistics
PubMed Score 119.35
PubMed score by year
PubTator Score 67.86
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title