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Tdark
LAGE3
EKC/KEOPS complex subunit LAGE3

Protein Summary
Description
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex. This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357360
  • ENSP00000349923
  • ENSG00000196976

Symbol
  • DXS9879E
  • ESO3
  • ITBA2
  • CVG5
  • ESO3
  • Pcc1
  • ITBA2
  • GAMOS2
  • DXS9879E
  • DXS9951E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.68
kinase perturbation
0.66
tissue sample
0.66
disease perturbation
0.62
cell type or tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.83   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.83   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
GON7
Tdark
Novelty:  0.21994743
p_int:  0.999999927
p_ni:  6.7e-8
p_wrong:  5e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
SMS
Tchem
Family:  Enzyme
Novelty:  0.02447112
p_int:  0.999999454
p_ni:  3.5e-8
p_wrong:  5.11e-7
Data Source:  BioPlex
HYKK
Tbio
Family:  Enzyme
Novelty:  0.11408577
p_int:  0.999998626
p_ni:  0.000001374
Score:  0.197
Data Source:  BioPlex,STRINGDB
UBXN4
Tbio
Novelty:  0.16206743
p_int:  0.999996893
p_ni:  0.000001071
p_wrong:  0.000002037
Data Source:  BioPlex
TPRKB
Tbio
Novelty:  0.1035085
p_int:  0.999995513
p_ni:  0.000004484
p_wrong:  3e-9
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
TP53RK
Tbio
Family:  Kinase
Novelty:  0.04302252
p_int:  0.999945209
p_ni:  0.000054791
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
PRAME
Tbio
Novelty:  0.00543263
p_int:  0.999815525
p_ni:  0.000184092
p_wrong:  3.82e-7
Score:  0.419
Data Source:  BioPlex,STRINGDB
RUFY2
Tbio
Novelty:  0.50188929
p_int:  0.999600391
p_ni:  0.000399362
p_wrong:  2.47e-7
Data Source:  BioPlex
MALT1
Tchem
Novelty:  0.00367231
p_int:  0.99919865
p_ni:  0.000044343
p_wrong:  0.000757007
Data Source:  BioPlex
PDZD8
Tbio
Novelty:  0.09015543
p_int:  0.999154832
p_ni:  0.000845168
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
1
3
87.7
red blood cell distribution width
1
1
1
79.3
erythrocyte count
1
1
1
70.2
hemolysis
1
1
0
3.8
68.3
neutrophil count
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
87.7
red blood cell distribution width
1
79.3
erythrocyte count
1
70.2
hemolysis
0
3.8
68.3
neutrophil count
1
36.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 51.83
PubMed score by year
PubTator Score 10.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title