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Tclin
LAG3
Lymphocyte activation gene 3 protein

Protein Summary
Description
Involved in lymphocyte activation. Binds to HLA class-II antigens. Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000203629
  • ENSP00000203629
  • ENSG00000089692
  • ENST00000441671
  • ENSP00000413825

Symbol
  • FDC
  • CD223
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
cell type or tissue
0.83
gene perturbation
0.75
biological process
0.59
PubMedID
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1116.54   (req: < 5)
Gene RIFs: 130   (req: <= 3)
Antibodies: 752   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1116.54   (req: >= 5)
Gene RIFs: 130   (req: > 3)
Antibodies: 752   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1