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Tbio
LAD1
Ladinin-1

Protein Summary
Description
Anchoring filament protein which is a component of the basement membrane zone. The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391967
  • ENSP00000375829
  • ENSG00000159166

Symbol
  • LAD
  • LadA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.9
interacting protein
0.85
gene perturbation
0.76
transcription factor perturbation
0.61
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.97   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.97   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
AHI1
Tbio
Novelty:  0.01180688
p_int:  0.999967948
p_ni:  0.000032052
Data Source:  BioPlex
FLNB
Tbio
Novelty:  0.00568768
p_int:  0.999967706
p_ni:  0.000032294
Data Source:  BioPlex
FLNA
Tbio
Novelty:  0.00156479
p_int:  0.999953904
p_ni:  0.000046096
Data Source:  BioPlex
FLNC
Tbio
Novelty:  0.00463205
p_int:  0.99993859
p_ni:  0.00006141
Data Source:  BioPlex
TIPARP
Tbio
Family:  Enzyme
Novelty:  0.00433138
p_int:  0.999829051
p_ni:  0.000170949
Data Source:  BioPlex
RPL7A
Tbio
Novelty:  0.01674027
p_int:  0.999692986
p_ni:  0.000307014
Data Source:  BioPlex
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
p_int:  0.999008941
p_ni:  0.000991059
Data Source:  BioPlex
RFLNB
Tbio
Novelty:  0.09562879
p_int:  0.998843408
p_ni:  0.001154428
p_wrong:  0.000002164
Data Source:  BioPlex
KLHL18
Tdark
Novelty:  0.52915213
p_int:  0.990506981
p_ni:  0.009255231
p_wrong:  0.000237788
Data Source:  BioPlex
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.984963728
p_ni:  0.015036144
p_wrong:  1.28e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
0
8.5
68.6
balding measurement
1
1
1
64.4
electrocardiography
1
1
3
29
left ventricular structural measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
0
8.5
68.6
balding measurement
1
64.4
electrocardiography
3
29
left ventricular structural measurement
1
14.2
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ladinin 1
VGNC:10701
738395
Mouse
MGI:109343
16763
Rat
RGD:1310652
313325
Dog
ladinin 1
VGNC:42561
607639
Horse
ladinin 1
VGNC:19560
100063440
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ladinin 1
Mouse
Rat
Dog
ladinin 1
Horse
ladinin 1
Publication Statistics
PubMed Score 37.97
PubMed score by year
PubTator Score 136.74
PubTator score by year
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Related Publications
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PMID
Year
Title