You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LACTB2
Endoribonuclease LACTB2

Protein Summary
Description
Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276590
  • ENSP00000276590
  • ENSG00000147592
  • ENST00000522447
  • ENSP00000428801

Symbol
  • CGI-83
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
transcription factor binding site profile
0.87
histone modification site profile
0.71
PubMedID
0.69
cell line
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.87   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.87   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
OGA
Tchem
Family:  Enzyme
Novelty:  0.00035723
p_int:  0.989322558
p_ni:  0.010677442
Score:  0.54
Data Source:  BioPlex,STRINGDB
XKR9
Tdark
Novelty:  0.57519937
Score:  0.873
Data Source:  STRINGDB
UBE2H
Tbio
Novelty:  0.03259425
Score:  0.833
Data Source:  STRINGDB
SLCO5A1
Tbio
Family:  Transporter
Novelty:  0.17025746
Score:  0.756
Data Source:  STRINGDB
SFT2D2
Tdark
Novelty:  1.03145192
Score:  0.692
Data Source:  STRINGDB
STAC
Tbio
Novelty:  0.01982527
Score:  0.682
Data Source:  STRINGDB
NDUFA9
Tclin
Family:  Enzyme
Novelty:  0.00637307
Score:  0.633
Data Source:  STRINGDB
HAGH
Tbio
Family:  Enzyme
Novelty:  0.00689153
Score:  0.571
Data Source:  STRINGDB
OLA1
Tchem
Family:  Enzyme
Novelty:  0.03431517
Score:  0.554
Data Source:  STRINGDB
REXO2
Tbio
Family:  Enzyme
Novelty:  0.0114609
Score:  0.553
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
snoring measurement
4
2
3
1
60.8
erythrocyte cadmium measurement
1
1
1
48.5
cortical surface area measurement
1
1
0
5.9
29
waist circumference
1
1
1
21.5
BMI-adjusted waist circumference
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
snoring measurement
3
1
60.8
erythrocyte cadmium measurement
1
48.5
cortical surface area measurement
0
5.9
29
waist circumference
1
21.5
BMI-adjusted waist circumference
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lactamase beta 2
VGNC:13173
464505
Macaque
lactamase beta 2
695035
Mouse
MGI:2442551
212442
Rat
RGD:1307876
297768
Dog
lactamase beta 2
VGNC:42560
486990
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lactamase beta 2
Macaque
lactamase beta 2
Mouse
Rat
Dog
lactamase beta 2
Publication Statistics
PubMed Score 5.87
PubMed score by year
PubTator Score 2.50
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title