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Tchem
L3MBTL3
Lethal(3)malignant brain tumor-like protein 3

Protein Summary
Description
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity). This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361794
  • ENSP00000354526
  • ENSG00000198945
  • ENST00000368136
  • ENSP00000357118
  • ENST00000368139
  • ENSP00000357121
  • ENST00000526019
  • ENSP00000436706
  • ENST00000529410
  • ENSP00000431962
  • ENST00000533560
  • ENSP00000437185

Symbol
  • KIAA1798
  • MBT1
  • MBT1
  • MBT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
virus
0.66
viral protein
0.59
virus perturbation
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.72   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.72   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 63
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (63)
CHEMBL2426365
Rendered image for CHEMBL2426365
UNC1215
Rendered image for UNC1215
CHEMBL3134130
Rendered image for CHEMBL3134130
CHEMBL2426360
Rendered image for CHEMBL2426360
CHEMBL2426366
Rendered image for CHEMBL2426366
CHEMBL2426498
Rendered image for CHEMBL2426498
CHEMBL3134144
Rendered image for CHEMBL3134144
CHEMBL2426367
Rendered image for CHEMBL2426367
CHEMBL3134146
Rendered image for CHEMBL3134146
CHEMBL2426368
Rendered image for CHEMBL2426368
Protein-Protein Interactions (35)
PRMT2
Tbio
Family:  Epigenetic
Novelty:  0.04121581
p_int:  0.999999915
p_ni:  8.3e-8
p_wrong:  2e-9
Score:  0.586
Data Source:  BioPlex,STRINGDB
SAMD13
Tdark
Novelty:  0.90979782
p_int:  0.99999978
p_wrong:  2.2e-7
Score:  0.685
Data Source:  BioPlex,STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.999999004
p_ni:  9.95e-7
Score:  0.163
Data Source:  BioPlex,STRINGDB
SAMD1
Tdark
Novelty:  0.21956379
p_int:  0.999998112
p_ni:  0.000001888
Score:  0.834
Data Source:  BioPlex,STRINGDB
DPPA4
Tbio
Novelty:  0.05764302
p_int:  0.999225887
p_ni:  0.000005613
p_wrong:  0.0007685
Score:  0.692
Data Source:  BioPlex,STRINGDB
TDRD3
Tbio
Family:  Epigenetic
Novelty:  0.07637876
Score:  0.538
Data Source:  STRINGDB
PHF20L1
Tbio
Family:  Epigenetic
Novelty:  0.23101523
Score:  0.52
Data Source:  STRINGDB
E2F6
Tbio
Family:  TF
Novelty:  0.00753541
Score:  0.516
Data Source:  STRINGDB
PRKAA2
Tchem
Family:  Kinase
Novelty:  0.01795523
Score:  0.516
Data Source:  STRINGDB
TDRD12
Tdark
Family:  Epigenetic
Novelty:  0.2276017
Score:  0.514
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (65)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
5
6
97.8
C-reactive protein measurement
5
5
5
97.1
heel bone mineral density
3
4
7
95.8
BMI-adjusted waist-hip ratio
6
5
6
93.6
sex hormone-binding globulin measurement
4
2
4
90.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
6
97.8
C-reactive protein measurement
5
97.1
heel bone mineral density
7
95.8
BMI-adjusted waist-hip ratio
6
93.6
sex hormone-binding globulin measurement
4
90.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
L3MBTL3, histone methyl-lysine binding protein
VGNC:14845
462996
Macaque
L3MBTL3, histone methyl-lysine binding protein
710947
Mouse
MGI:2143628
237339
Rat
RGD:1305474
309550
Dog
L3MBTL3, histone methyl-lysine binding protein
VGNC:53732
612721
Species
Name
OMA
EggNOG
Inparanoid
Chimp
L3MBTL3, histone methyl-lysine binding protein
Macaque
L3MBTL3, histone methyl-lysine binding protein
Mouse
Rat
Dog
L3MBTL3, histone methyl-lysine binding protein
Publication Statistics
PubMed Score 33.72
PubMed score by year
PubTator Score 6.40
PubTator score by year
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Related Publications
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PMID
Year
Title