Tchem L3MBTL1 Lethal(3)malignant brain tumor-like protein 1

Protein Summary

Description

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q9Y468
• B4DRC9
• E1P5W7
• Q5H8Y8
• Q5H8Y9
• Q8IUV7
• Q9H1E6
• Q9H1G5
• Q9UG06
• Q9UJB9
• Q9Y4C9
• H-l(3)mbt

Gene Name

• L3MBTL1

Ensembl ID

• ENST00000373135
• ENSP00000362227
• ENSG00000185513
• ENST00000422861
• ENSP00000410139
• ENST00000427442
• ENSP00000402107

Symbol

• KIAA0681
• L3MBT
• L3MBTL
• L3MBTL
• ZC2HC3
• H-L(3)MBT
• dJ138B7.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.81
protein domain	0.73
molecular function	0.7
biological process	0.68
tissue sample	0.67

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Lethal(3)malignant Brain Tumor-like Protein 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Lethal(3)malignant Brain Tumor-like Protein 1

DTO Classes

Protein / Epigenetic Regulator / Reader / Methyl-lysine/arginine Binding Protein / Mbt Domain / Lethal(3)malignant Brain Tumor-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.86   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.86   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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1 – 1 of 1

cefsulodin

L3MBTL1Tchem TF; Epigenetic

pIC50 : 7.01

Active Ligands (2)

Explore Active Ligands

1 – 2 of 2

I-OME Tyrphostin AG 538

L3MBTL1Tchem TF; Epigenetic

pIC50 : 6.55

CHEMBL2426365

L3MBTL1Tchem TF; Epigenetic

pIC50 : 7.41

Protein-Protein Interactions (99)

Explore Interacting Targets

1 – 10 of 99

• See Interactions on String-DB

ZNF644

Tbio

Family:  TF

Novelty:  0.12816167

p_int:  0.999998335

p_ni:  0.000001665

Score:  0.161

Data Source:  BioPlex,STRINGDB

SATB2

Tbio

Family:  TF

Novelty:  0.00405935

p_int:  0.999998305

p_ni:  0.000001695

Data Source:  BioPlex

SAMD11

Tdark

Novelty:  0.32977476

p_int:  0.999793874

p_ni:  0.000206126

Score:  0.181

Data Source:  BioPlex,STRINGDB

FAM208B

Tdark

Novelty:  1.21420488

p_int:  0.999683843

p_ni:  0.000316157

Score:  0.181

Data Source:  BioPlex,STRINGDB

WIZ

Tbio

Family:  TF

Novelty:  0.04458547

p_int:  0.999637786

p_ni:  0.000362214

Score:  0.304

Data Source:  BioPlex,STRINGDB

EHMT2

Tchem

Family:  Epigenetic

Novelty:  0.00262578

p_int:  0.999421648

p_ni:  0.000578351

p_wrong:  1e-9

Score:  0.534

Data Source:  BioPlex,STRINGDB

ZNF195

Tdark

Family:  TF

Novelty:  0.23029736

p_int:  0.999178558

p_ni:  0.000821383

p_wrong:  5.9e-8

Score:  0.219

Data Source:  BioPlex,STRINGDB

ANAPC1

Tbio

Family:  Enzyme

Novelty:  0.0521845

p_int:  0.998176417

p_ni:  0.001823583

Score:  0.151

Data Source:  BioPlex,STRINGDB

EHMT1

Tchem

Family:  Epigenetic

Novelty:  0.00821799

p_int:  0.99752907

p_ni:  0.00247093

Score:  0.48

Data Source:  BioPlex,STRINGDB

CBX2

Tchem

Family:  Epigenetic

Novelty:  0.01952928

p_int:  0.996972942

p_ni:  0.001899011

p_wrong:  0.001128046

Score:  0.392

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (6)

Gene expression (Transcription) (R-HSA-74160)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	Regulation of TP53 Activity	160 targets	R-HSA-5633007
Reactome	Regulation of TP53 Activity through Methylation	19 targets	R-HSA-6804760

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Regulation of TP53 Activity	160 targets	R-HSA-5633007
Regulation of TP53 Activity through Methylation	19 targets	R-HSA-6804760

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (9)

Components (5)

Processes (7)

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1 – 9 of 9

GO Term	Evidence	Assigned by
chromatin binding	Inferred from Direct Assay (IDA)	UniProtKB
methylated histone binding	Inferred from Direct Assay (IDA)	UniProtKB
nucleosomal histone binding	Inferred from Direct Assay (IDA)	UniProtKB
nucleosome binding	Inferred from Direct Assay (IDA)	UniProtKB
histone binding	Inferred from Physical Interaction (IPI)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	UniProtKB
SAM domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
DNA-binding transcription factor activity	Inferred from Electronic Annotation (IEA)	InterPro
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	1	1	1		53.3
mean reticulocyte volume	EFO_0010701	1	1	1		46.1
monocyte count	EFO_0005091	1	1	1		13.6
mean platelet volume	EFO_0004584	1	1	1		13.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	1		53.3
mean reticulocyte volume	EFO_0010701	1		46.1
monocyte count	EFO_0005091	1		13.6
mean platelet volume	EFO_0004584	1		13.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Chromatin regulator
Complete proteome
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
mean platelet volume
mean reticulocyte volume
monocyte count
type II diabetes mellitus

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	L3MBTL1, histone methyl-lysine binding protein	VGNC:14861	469947
Macaque	L3MBTL1, histone methyl-lysine binding protein		695694
Mouse	L3MBTL1 histone methyl-lysine binding protein	MGI:2676663	241764
Rat	L3MBTL1, histone methyl-lysine binding protein	RGD:1307316	311613
Dog	L3MBTL1, histone methyl-lysine binding protein	VGNC:54652	477231

Species	Name	OMA	EggNOG	Inparanoid
Chimp	L3MBTL1, histone methyl-lysine binding protein
Macaque	L3MBTL1, histone methyl-lysine binding protein
Mouse	L3MBTL1 histone methyl-lysine binding protein
Rat	L3MBTL1, histone methyl-lysine binding protein
Dog	L3MBTL1, histone methyl-lysine binding protein

Publication Statistics

PubMed Score 42.86

PubMed score by year

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PubTator Score 26.35

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Related Publications

Text Mined References (33)

GeneRif Annotations (15)

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PMID	Year	Title