Tchem L3MBTL1 Lethal(3)malignant brain tumor-like protein 1

Protein Summary

Description

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q9Y468
• B4DRC9
• E1P5W7
• Q5H8Y8
• Q5H8Y9
• Q8IUV7
• Q9H1E6
• Q9H1G5
• Q9UG06
• Q9UJB9
• Q9Y4C9
• H-l(3)mbt

Gene Name

• L3MBTL1

Ensembl ID

• ENST00000373135
• ENSP00000362227
• ENSG00000185513
• ENST00000422861
• ENSP00000410139
• ENST00000427442
• ENSP00000402107

Symbol

• KIAA0681
• L3MBT
• L3MBTL
• L3MBTL
• ZC2HC3
• H-L(3)MBT
• dJ138B7.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.81
protein domain	0.73
molecular function	0.7
biological process	0.68
tissue sample	0.67

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Lethal(3)malignant Brain Tumor-like Protein 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Lethal(3)malignant Brain Tumor-like Protein 1

DTO Classes

Protein / Epigenetic Regulator / Reader / Methyl-lysine/arginine Binding Protein / Mbt Domain / Lethal(3)malignant Brain Tumor-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.13   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.13   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1