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Tdark
L3HYPDH
Trans-3-hydroxy-L-proline dehydratase

Protein Summary
Description
Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. The protein encoded by this gene is a dehydratase that converts trans-3-hydroxy-L-proline to delta(1)-pyrroline-2-carboxylate. This enzyme may function to degrade dietary proteins that contain trans-3-hydroxy-L-proline as well as other proteins such as collagen IV. The encoded protein can be converted to an epimerase by changing a threonine to a cysteine at a catalytic site. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247194
  • ENSP00000247194
  • ENSG00000126790

Symbol
  • C14orf149
  • C14orf149
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
gene perturbation
0.74
transcription factor binding site profile
0.72
tissue sample
0.65
disease
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
CCNE2
Tbio
Novelty:  0.00795182
p_int:  0.999971214
p_ni:  0.000018502
p_wrong:  0.000010284
Score:  0.193
Data Source:  BioPlex,STRINGDB
DIXDC1
Tbio
Novelty:  0.05901474
p_int:  0.999971131
p_ni:  0.000028869
Score:  0.282
Data Source:  BioPlex,STRINGDB
CPZ
Tbio
Family:  Enzyme
Novelty:  0.00100967
p_int:  0.999428964
p_ni:  0.000571036
Score:  0.282
Data Source:  BioPlex,STRINGDB
UTRN
Tchem
Novelty:  0.0018541
p_int:  0.998757677
p_ni:  0.001242323
Score:  0.228
Data Source:  BioPlex,STRINGDB
RPL22L1
Tdark
Novelty:  0.19211417
p_int:  0.977496887
p_ni:  0.022503112
p_wrong:  1e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
ALDH7A1
Tbio
Family:  Enzyme
Novelty:  0.00069494
p_int:  0.954394106
p_ni:  0.045605894
Score:  0.378
Data Source:  BioPlex,STRINGDB
POLR3C
Tbio
Family:  Enzyme
Novelty:  0.05778457
p_int:  0.908686949
p_ni:  0.084060431
p_wrong:  0.00725262
Score:  0.228
Data Source:  BioPlex,STRINGDB
IP6K3
Tbio
Family:  Kinase
Novelty:  0.13072912
p_int:  0.828277853
p_ni:  0.171722105
p_wrong:  4.2e-8
Score:  0.232
Data Source:  BioPlex,STRINGDB
ACOT9
Tbio
Family:  Enzyme
Novelty:  0.17405187
p_int:  0.82266617
p_ni:  0.177333664
p_wrong:  1.66e-7
Score:  0.193
Data Source:  BioPlex,STRINGDB
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.769826884
p_ni:  0.230173116
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
2
0
7.2
54.3
monocyte count
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
7.2
54.3
monocyte count
1
38.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trans-L-3-hydroxyproline dehydratase
VGNC:9160
452942
Macaque
trans-L-3-hydroxyproline dehydratase
702076
Mouse
MGI:1914467
67217
Rat
RGD:1305721
314214
Dog
trans-L-3-hydroxyproline dehydratase
VGNC:42557
490715
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trans-L-3-hydroxyproline dehydratase
Macaque
trans-L-3-hydroxyproline dehydratase
Mouse
Rat
Dog
trans-L-3-hydroxyproline dehydratase
Publication Statistics
PubMed Score 4.07
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title