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Tbio
L1CAM
Neural cell adhesion molecule L1

Protein Summary
Description
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361699
  • ENSP00000355380
  • ENSG00000198910
  • ENST00000361981
  • ENSP00000354712
  • ENST00000370055
  • ENSP00000359072
  • ENST00000370060
  • ENSP00000359077

Symbol
  • CAML1
  • MIC5
  • S10
  • HSAS
  • MASA
  • MIC5
  • SPG1
  • CAML1
  • CD171
  • HSAS1
  • N-CAML1
  • NCAM-L1
  • N-CAM-L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.88
biological term
0.86
ligand (protein) perturbation
0.83
phenotype
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 349.67   (req: < 5)
Gene RIFs: 160   (req: <= 3)
Antibodies: 995   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 349.67   (req: >= 5)
Gene RIFs: 160   (req: > 3)
Antibodies: 995   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.999990528
p_ni:  0.000009422
p_wrong:  5e-8
Score:  0.154
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999989238
p_ni:  0.000010747
p_wrong:  1.5e-8
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.999530562
p_ni:  0.000083583
p_wrong:  0.000385854
Data Source:  BioPlex
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999519561
p_ni:  0.000106487
p_wrong:  0.000373952
Data Source:  BioPlex
ANK2
Tbio
Novelty:  0.00528351
Score:  0.969
Data Source:  Reactome,STRINGDB
RANBP9
Tbio
Novelty:  0.02182372
Score:  0.967
Data Source:  Reactome,STRINGDB
NCAN
Tbio
Novelty:  0.00401824
Score:  0.966
Data Source:  Reactome,STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.965
Data Source:  Reactome,STRINGDB
NCAM1
Tbio
Novelty:  0.00020994
Score:  0.963
Data Source:  Reactome,STRINGDB
CNTN1
Tbio
Novelty:  0.00741212
Score:  0.961
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Developmental Biology
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Axon guidance
Basigin interactions
Cell surface interactions at the vascular wall
Developmental Biology
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
53.7
albumin:globulin ratio measurement
1
1
1
36.9
1
1
0
1.2
17.8
1
1
0
1.3
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
53.7
albumin:globulin ratio measurement
1
36.9
0
1.2
17.8
0
1.3
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
L1 cell adhesion molecule
VGNC:12461
450117
Mouse
MGI:96721
16728
Rat
RGD:619777
50687
Dog
L1 cell adhesion molecule
VGNC:42556
492244
Horse
L1 cell adhesion molecule
VGNC:19557
100059024
Species
Name
OMA
EggNOG
Inparanoid
Chimp
L1 cell adhesion molecule
Mouse
Rat
Dog
L1 cell adhesion molecule
Horse
L1 cell adhesion molecule
Publication Statistics
PubMed Score 349.67
PubMed score by year
PubTator Score 1443.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title