L1CAM
Neural cell adhesion molecule L1
Protein Summary
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus) ...more
- ENST00000361699
- ENSP00000355380
- ENSG00000198910
- ENST00000361981
- ENSP00000354712
- ENST00000370055
- ENSP00000359072
- ENST00000370060
- ENSP00000359077
- CAML1
- MIC5
- S10
- HSAS
- MASA
- MIC5
- SPG1
- CAML1
- CD171
- HSAS1
- N-CAML1
- NCAM-L1
- N-CAM-L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
transcription factor perturbation | 0.88 | ||
biological term | 0.86 | ||
ligand (protein) perturbation | 0.83 | ||
phenotype | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 349.67 (req: < 5)
Gene RIFs: 160 (req: <= 3)
Antibodies: 995 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 349.67 (req: >= 5)
Gene RIFs: 160 (req: > 3)
Antibodies: 995 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (96)
DGUOK
Family: Kinase
Novelty: 0.00897987
p_int: 0.999990528
p_ni: 0.000009422
p_wrong: 5e-8
Score: 0.154
Data Source: BioPlex,STRINGDB
DNAAF2
Novelty: 0.01254416
p_int: 0.999989238
p_ni: 0.000010747
p_wrong: 1.5e-8
Data Source: BioPlex
HAX1
Novelty: 0.00749205
p_int: 0.999530562
p_ni: 0.000083583
p_wrong: 0.000385854
Data Source: BioPlex
NUFIP1
Novelty: 0.11726869
p_int: 0.999519561
p_ni: 0.000106487
p_wrong: 0.000373952
Data Source: BioPlex
Nearest Tclin Targets
Pathways (12)
Reactome (9)
KEGG (2)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Basigin interactions | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Developmental Biology | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Basigin interactions | ||||
Cell surface interactions at the vascular wall | ||||
Developmental Biology | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (2)
Components (9)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.2 | 53.7 | |||||
albumin:globulin ratio measurement | 1 | 1 | 1 | 36.9 | |||||
1 | 1 | 0 | 1.2 | 17.8 | |||||
1 | 1 | 0 | 1.3 | 15.8 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 53.7 | |||||
albumin:globulin ratio measurement | 1 | 36.9 | |||||
0 | 1.2 | 17.8 | |||||
0 | 1.3 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | L1 cell adhesion molecule | VGNC:12461 | 450117 | |||||
Mouse | MGI:96721 | 16728 | ||||||
Rat | RGD:619777 | 50687 | ||||||
Dog | L1 cell adhesion molecule | VGNC:42556 | 492244 | |||||
Horse | L1 cell adhesion molecule | VGNC:19557 | 100059024 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | L1 cell adhesion molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | L1 cell adhesion molecule | |||||
Horse | L1 cell adhesion molecule | |||||
Publication Statistics
PubMed Score 349.67
PubMed score by year
PubTator Score 1443.88
PubTator score by year
Related Publications
Text Mined References (243)
GeneRif Annotations (160)
Items per page:
0 of 0
PMID | Year | Title |
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