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Tbio
L0R8F8
MIEF1 upstream open reading frame protein

Protein Summary
Description
Involved in the regulation of mitochondrial fission mediated by DNM1L (PubMed:29083303). Positively regulates mitochondrial translation (PubMed:30215512). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000637854
  • ENSP00000490747
  • ENSG00000100335

Symbol
  • MID51
  • SMCR7L
  • AltMIEF1
  • HSU79252
  • MIEF1-MP
  • dJ1104E15.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
drug perturbation
0.96
kinase perturbation
0.84
molecular function
0.84
microRNA
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
FIS1
Tbio
Novelty:  0.0033607
Score:  0.931
Data Source:  STRINGDB
MFF
Tbio
Novelty:  0.00411615
Score:  0.896
Data Source:  STRINGDB
DNM1L
Tchem
Novelty:  0.00151314
Score:  0.843
Data Source:  STRINGDB
MFN1
Tbio
Novelty:  0.00372574
Score:  0.77
Data Source:  STRINGDB
MB21D2
Tdark
Novelty:  0.48908631
Score:  0.723
Data Source:  STRINGDB
MFN2
Tbio
Novelty:  0.00137876
Score:  0.711
Data Source:  STRINGDB
OPA1
Tchem
Novelty:  0.0031868
Score:  0.704
Data Source:  STRINGDB
CHST12
Tbio
Family:  Enzyme
Novelty:  0.04560641
Score:  0.675
Data Source:  STRINGDB
ITPRIPL2
Tdark
Novelty:  1.92099276
Score:  0.658
Data Source:  STRINGDB
TOMM20
Tbio
Novelty:  0.00275824
Score:  0.658
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
2
5.9
89.6
alkaline phosphatase measurement
2
2
2
5.9
89.6
serum IgG glycosylation measurement
2
2
6
87.8
serum IgG glycosylation measurement
2
2
6
87.8
cognitive function measurement
3
3
10
81.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
5.9
89.6
alkaline phosphatase measurement
2
5.9
89.6
serum IgG glycosylation measurement
6
87.8
serum IgG glycosylation measurement
6
87.8
cognitive function measurement
10
81.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial elongation factor 1
VGNC:5281
744438
Macaque
mitochondrial elongation factor 1
703747
Mouse
MGI:2146020
239555
Rat
RGD:1359173
315141
Dog
mitochondrial elongation factor 1
VGNC:43226
610014
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial elongation factor 1
Macaque
mitochondrial elongation factor 1
Mouse
Rat
Dog
mitochondrial elongation factor 1
Publication Statistics
PubMed Score 28.14
PubMed score by year
PubTator Score 11.55
PubTator score by year
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Related Publications
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PMID
Year
Title