Tdark L0R8F8 MIEF1 upstream open reading frame protein

Protein Summary

Description

Involved in the regulation of mitochondrial fission mediated by DNM1L (PubMed:29083303). Positively regulates mitochondrial translation (PubMed:30215512). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable).

Uniprot Accession IDs

• L0R8F8

Gene Name

• MIEF1

Ensembl ID

• ENST00000637854
• ENSP00000490747
• ENSG00000100335

Symbol

• MID51
• SMCR7L
• AltMIEF1
• HSU79252
• MIEF1-MP
• dJ1104E15.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
drug perturbation	0.96
kinase perturbation	0.84
molecular function	0.84
microRNA	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.38   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.38   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0