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Tbio
KY
Kyphoscoliosis peptidase

Protein Summary
Description
Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity). The protein encoded by this gene belongs to the transglutaminase-like superfamily. The protein is involved in the function, maturation and stabilization of the neuromuscular junction and may be required for normal muscle growth. Mutations in this gene are associated with myopathy, myofibrillar, 7. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423778
  • ENSP00000397598
  • ENSG00000174611
  • ENST00000508956
  • ENSP00000421297

Symbol
  • MFM7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.77
histone modification site profile
0.64
cell line
0.57
gene perturbation
0.53
PubMedID
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.69   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.69   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
FLNC
Tbio
Novelty:  0.00463205
Score:  0.772
Data Source:  STRINGDB
MYBPC1
Tbio
Novelty:  0.041267
Score:  0.767
Data Source:  STRINGDB
MSS51
Tbio
Novelty:  0.06388791
Score:  0.715
Data Source:  STRINGDB
ANKRD29
Tdark
Novelty:  1.29202649
Score:  0.694
Data Source:  STRINGDB
KLHDC1
Tbio
Novelty:  1.2348626
Score:  0.648
Data Source:  STRINGDB
SPSB3
Tdark
Novelty:  0.07215887
Score:  0.615
Data Source:  STRINGDB
NCOA7
Tbio
Novelty:  0.08842763
Score:  0.554
Data Source:  STRINGDB
HAS3
Tbio
Family:  Enzyme
Novelty:  0.03898687
Score:  0.546
Data Source:  STRINGDB
HAS1
Tbio
Family:  Enzyme
Novelty:  0.02014779
Score:  0.546
Data Source:  STRINGDB
HAS2
Tbio
Family:  Enzyme
Novelty:  0.0025539
Score:  0.546
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
3
3
65.6
waist circumference
1
2
2
62
BMI-adjusted hip circumference
1
1
1
17.8
high density lipoprotein cholesterol measurement
1
1
1
5.7
sleep duration
1
1
1
5.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
3
65.6
waist circumference
2
62
BMI-adjusted hip circumference
1
17.8
high density lipoprotein cholesterol measurement
1
5.7
sleep duration
1
5.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kyphoscoliosis peptidase
VGNC:1859
470932
Macaque
kyphoscoliosis peptidase
717233
Mouse
MGI:96709
16716
Rat
RGD:1305407
315962
Dog
kyphoscoliosis peptidase
VGNC:42552
485670
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kyphoscoliosis peptidase
Macaque
kyphoscoliosis peptidase
Mouse
Rat
Dog
kyphoscoliosis peptidase
Publication Statistics
PubMed Score 7.69
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title