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Tbio
KXD1
KxDL motif-containing protein 1

Protein Summary
Description
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May be involved in the biogenesis of lysosome-related organelles such as melanosomes (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222307
  • ENSP00000222307
  • ENSG00000105700
  • ENST00000539106
  • ENSP00000438903
  • ENST00000540691
  • ENSP00000443549
  • ENST00000595073
  • ENSP00000471554
  • ENST00000599319
  • ENSP00000468990
  • ENST00000600654
  • ENSP00000472678
  • ENST00000602094
  • ENSP00000472836

Symbol
  • C19orf50
  • KXDL
  • BORCS4
  • MST096
  • MSTP096
  • C10orf50
  • C19orf50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor
0.69
transcription factor perturbation
0.68
cell type or tissue
0.65
histone modification site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.91   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.91   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (158)
BORCS7
Tbio
Novelty:  0.14135922
p_int:  0.99999992
p_ni:  8e-8
Score:  0.965
Data Source:  BioPlex,STRINGDB
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.999999845
p_ni:  1.55e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
TPM1
Tbio
Novelty:  0.00261206
p_int:  0.999984834
p_ni:  0.000014383
p_wrong:  7.83e-7
Score:  0.768
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.999977381
p_ni:  0.000022619
Score:  0.873
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.998855075
p_ni:  0.001052442
p_wrong:  0.000092482
Score:  0.239
Data Source:  BioPlex,STRINGDB
LAMTOR1
Tbio
Novelty:  0.04952213
p_int:  0.998731953
p_ni:  0.001268047
Data Source:  BioPlex
TRIML2
Tdark
Family:  Enzyme
Novelty:  0.38455379
p_int:  0.998169057
p_ni:  0.001830943
Score:  0.625
Data Source:  BioPlex,STRINGDB
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.998109418
p_ni:  0.001889871
p_wrong:  7.11e-7
Score:  0.443
Data Source:  BioPlex,STRINGDB
CCDC136
Tbio
Novelty:  0.09279967
p_int:  0.994280149
p_ni:  0.005715039
p_wrong:  0.000004812
Score:  0.527
Data Source:  BioPlex,STRINGDB
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.994189067
p_ni:  0.005810924
p_wrong:  9e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
3
3
3
86.5
3
1
0
1.1
83.1
Oral ulcer
1
1
0
1.1
76.3
blood protein measurement
1
1
1
71.5
blood metabolite measurement
1
1
1
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
3
86.5
0
1.1
83.1
Oral ulcer
0
1.1
76.3
blood protein measurement
1
71.5
blood metabolite measurement
1
68
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KxDL motif containing 1
VGNC:11152
735620
Mouse
MGI:1922870
75620
Rat
RGD:1562866
498606
Dog
KxDL motif containing 1
VGNC:42551
476666
Horse
KxDL motif containing 1
VGNC:19552
100070992
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KxDL motif containing 1
Mouse
Rat
Dog
KxDL motif containing 1
Horse
KxDL motif containing 1
Publication Statistics
PubMed Score 5.91
PubMed score by year
PubTator Score 0.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title