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Tbio
KTN1
Kinectin

Protein Summary
Description
Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395308
  • ENSP00000378719
  • ENSG00000126777
  • ENST00000395309
  • ENSP00000378720
  • ENST00000395311
  • ENSP00000378722
  • ENST00000395314
  • ENSP00000378725
  • ENST00000413890
  • ENSP00000394992
  • ENST00000438792
  • ENSP00000391964
  • ENST00000459737
  • ENSP00000432149

Symbol
  • CG1
  • KIAA0004
  • CG1
  • KNT
  • MU-RMS-40.19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
interacting protein
0.91
transcription factor perturbation
0.91
ligand (protein) perturbation
0.83
cell type or tissue
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.73   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.73   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (189)
CDR2
Tbio
Novelty:  0.00141419
p_int:  0.99998341
p_ni:  0.00001659
Score:  0.529
Data Source:  BioPlex,STRINGDB
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.999947902
p_ni:  0.000052098
Data Source:  BioPlex
PSMD7
Tbio
Family:  Enzyme
Novelty:  0.03090292
p_int:  0.999792922
p_ni:  0.000207078
Data Source:  BioPlex
EEF1D
Tbio
Novelty:  0.02480745
p_int:  0.99776642
p_ni:  0.00223358
Score:  0.939
Data Source:  BioPlex,STRINGDB
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.994102018
p_ni:  0.005897982
Data Source:  BioPlex
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.989371914
p_ni:  0.010628086
Data Source:  BioPlex
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.988225904
p_ni:  0.011774095
p_wrong:  1e-9
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.984740949
p_ni:  0.015259051
Data Source:  BioPlex
CAPN1
Tchem
Novelty:  0.00252811
p_int:  0.979580377
p_ni:  0.020419623
Score:  0.169
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.971305133
p_ni:  0.028694867
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate KTN1
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
RHO GTPase Effectors
RHO GTPases activate KTN1
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
putamen volume
2
6
0
15.1
97.1
pallidum volume
1
4
0
7.5
72.8
caudate nucleus volume
1
4
0
6.1
57.7
nucleus accumbens volume
1
3
0
5.8
40.6
brain volume measurement
1
1
0
48.9
31.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
putamen volume
0
15.1
97.1
pallidum volume
0
7.5
72.8
caudate nucleus volume
0
6.1
57.7
nucleus accumbens volume
0
5.8
40.6
brain volume measurement
0
48.9
31.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinectin 1
VGNC:3402
744347
Macaque
kinectin 1
697744
Mouse
MGI:109153
16709
Rat
RGD:1308719
361029
Dog
kinectin 1
VGNC:42550
480332
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinectin 1
Macaque
kinectin 1
Mouse
Rat
Dog
kinectin 1
Publication Statistics
PubMed Score 73.73
PubMed score by year
PubTator Score 77.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title