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Tbio
KSR1
Kinase suppressor of Ras 1

Protein Summary
Description
Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398988
  • ENSP00000381958
  • ENSG00000141068
  • ENST00000509603
  • ENSP00000438795

Symbol
  • KSR
  • KSR
  • RSU2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
molecular function
0.99
protein complex
0.99
hub protein
0.88
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.98   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 385   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.98   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 385   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (142)
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.999982188
p_ni:  0.000017812
Data Source:  BioPlex
PRMT2
Tbio
Family:  Epigenetic
Novelty:  0.04121581
p_int:  0.999851867
p_ni:  0.000145671
p_wrong:  0.000002462
Score:  0.201
Data Source:  BioPlex,STRINGDB
SDF4
Tbio
Novelty:  0.00105893
p_int:  0.998710774
p_ni:  0.001085184
p_wrong:  0.000204042
Score:  0.188
Data Source:  BioPlex,STRINGDB
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.997916549
p_ni:  0.001347322
p_wrong:  0.000736129
Score:  0.187
Data Source:  BioPlex,STRINGDB
MAP2K1
Tclin
Family:  Kinase
Novelty:  0.0005278
Score:  0.995
Data Source:  Reactome,STRINGDB
CNKSR2
Tbio
Family:  Enzyme
Novelty:  0.05451075
Score:  0.994
Data Source:  STRINGDB
MAP2K2
Tclin
Family:  Kinase
Novelty:  0.00706525
Score:  0.994
Data Source:  Reactome,STRINGDB
CNKSR1
Tchem
Family:  Enzyme
Novelty:  0.06710697
Score:  0.989
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.981
Data Source:  Reactome,STRINGDB
RAF1
Tclin
Family:  Kinase
Novelty:  0.00117121
Score:  0.97
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (48)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
88.6
2
1
0
1.1
72.3
monocyte percentage of leukocytes
2
1
2
64.9
1
1
0
1.1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
88.6
0
1.1
72.3
monocyte percentage of leukocytes
2
64.9
0
1.1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
kinase suppressor of ras 1
706388
Mouse
MGI:105051
16706
Rat
RGD:1308105
360573
Dog
kinase suppressor of ras 1
VGNC:42547
610451
Pig
kinase suppressor of ras 1
100511282
Species
Name
OMA
EggNOG
Inparanoid
Macaque
kinase suppressor of ras 1
Mouse
Rat
Dog
kinase suppressor of ras 1
Pig
kinase suppressor of ras 1
Publication Statistics
PubMed Score 175.98
PubMed score by year
PubTator Score 109.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title