You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
KRTDAP
Keratinocyte differentiation-associated protein

Protein Summary
Description
May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis. This gene encodes a protein which may function in the regulation of keratinocyte differentiation and maintenance of stratified epithelia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338897
  • ENSP00000339251
  • ENSG00000188508
  • ENST00000484218
  • ENSP00000470713

Symbol
  • KDAP
  • KDAP
  • UNQ467
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.63
gene perturbation
0.59
virus perturbation
0.5
PubMedID
0.49
tissue sample
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.32   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.32   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
SBSN
Tbio
Novelty:  0.05105712
Score:  0.716
Data Source:  STRINGDB
KPRP
Tdark
Novelty:  0.11744927
Score:  0.612
Data Source:  STRINGDB
LCE3D
Tbio
Novelty:  0.20614547
Score:  0.606
Data Source:  STRINGDB
DMKN
Tbio
Novelty:  0.08303199
Score:  0.593
Data Source:  STRINGDB
HRNR
Tbio
Novelty:  0.0316035
Score:  0.569
Data Source:  STRINGDB
CNFN
Tdark
Novelty:  0.15365561
Score:  0.566
Data Source:  STRINGDB
LOR
Tbio
Novelty:  0.0033781
Score:  0.562
Data Source:  STRINGDB
DSG1
Tbio
Novelty:  0.00142889
Score:  0.559
Data Source:  STRINGDB
SPRR2E
Tdark
Novelty:  0.78347788
Score:  0.545
Data Source:  STRINGDB
KIAA0232
Tdark
Novelty:  2.37569744
Score:  0.531
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
5
5
84.5
hemoglobin measurement
4
4
4
71.6
serum alanine aminotransferase measurement
2
1
1
6.9
70.1
phospholipids:total lipids ratio
1
1
1
63.9
high density lipoprotein cholesterol measurement
5
1
5
63.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
84.5
hemoglobin measurement
4
71.6
serum alanine aminotransferase measurement
1
6.9
70.1
phospholipids:total lipids ratio
1
63.9
high density lipoprotein cholesterol measurement
5
63.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratinocyte differentiation associated protein
VGNC:7683
455949
Macaque
keratinocyte differentiation associated protein
709120
Mouse
MGI:1928282
64661
Dog
keratinocyte differentiation associated protein
VGNC:42546
554216
Horse
keratinocyte differentiation associated protein
VGNC:19550
106782121
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratinocyte differentiation associated protein
Macaque
keratinocyte differentiation associated protein
Mouse
Dog
keratinocyte differentiation associated protein
Horse
keratinocyte differentiation associated protein
Publication Statistics
PubMed Score 10.32
PubMed score by year
PubTator Score 5.29
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title