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Tdark
KRTAP7-1
Keratin-associated protein 7-1

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000621162
  • ENSP00000479656
  • ENSG00000274749

Symbol
  • KAP7.1
  • KRTAP7.1
  • KAP7.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.53
cell type or tissue
0.46
cell line
0.45
tissue sample
0.34
transcription factor
0.34


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.87   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.87   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
KRTAP8-1
Tbio
Novelty:  0.18211237
Score:  0.813
Data Source:  STRINGDB
KRTAP11-1
Tbio
Novelty:  0.20865014
Score:  0.794
Data Source:  STRINGDB
KRTAP24-1
Tdark
Novelty:  0.3470695
Score:  0.778
Data Source:  STRINGDB
KRTAP15-1
Tdark
Novelty:  1.11971653
Score:  0.698
Data Source:  STRINGDB
KRTAP19-1
Tdark
Novelty:  8.12369581
Score:  0.685
Data Source:  STRINGDB
KRTAP13-1
Tdark
Novelty:  0.47013888
Score:  0.684
Data Source:  STRINGDB
KRTAP19-3
Tdark
Novelty:  1.7849221
Score:  0.671
Data Source:  STRINGDB
KRTAP6-2
Tdark
Novelty:  1.37501842
Score:  0.669
Data Source:  STRINGDB
KRTAP21-2
Tdark
Novelty:  0.86372091
Score:  0.666
Data Source:  STRINGDB
KRTAP19-5
Tdark
Novelty:  8.16087009
Score:  0.658
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.6
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.6
4.5
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1918613
71363
Rat
RGD:1560879
363741
Dog
keratin associated protein 7-1
VGNC:53032
100687847
Horse
keratin-associated protein 7-1
100630522
Cow
keratin associated protein 7-1
100296254
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
keratin associated protein 7-1
Horse
keratin-associated protein 7-1
Cow
keratin associated protein 7-1
Publication Statistics
PubMed Score 2.87
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title