KRTAP5-2
Keratin-associated protein 5-2
Protein Summary
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
- ENST00000412090
- ENSP00000400041
- ENSG00000205867
- ENST00000612541
- ENSP00000484511
- ENSG00000278489
- ENST00000628787
- ENSP00000487099
- ENSG00000281533
- KAP5-8
- KAP5.2
- KRTAP5-8
- KRTAP5.2
- KRTAP5.8
- KRTAP5-8
- KRTAP5.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell line | 0.69 | ||
cell type or tissue | 0.61 | ||
tissue | 0.46 | ||
microRNA | 0.45 | ||
tissue sample | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.15 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.15 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (81)
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (3)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
cathepsin D measurement | 1 | 2 | 2 | 90.1 | ||||||
cathepsin D measurement | 1 | 2 | 2 | 90.1 | ||||||
cathepsin D measurement | 1 | 2 | 2 | 90.1 | ||||||
hematocrit | 1 | 1 | 1 | 15.5 | ||||||
hematocrit | 1 | 1 | 1 | 15.5 | ||||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cathepsin D measurement | 2 | 90.1 | |||||
cathepsin D measurement | 2 | 90.1 | |||||
cathepsin D measurement | 2 | 90.1 | |||||
hematocrit | 1 | 15.5 | |||||
hematocrit | 1 | 15.5 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 0.15
PubMed score by year
PubTator Score 1.00
PubTator score by year
Related Publications
Text Mined References (3)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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