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Tdark
KRTAP5-2
Keratin-associated protein 5-2

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000412090
  • ENSP00000400041
  • ENSG00000205867
  • ENST00000612541
  • ENSP00000484511
  • ENSG00000278489
  • ENST00000628787
  • ENSP00000487099
  • ENSG00000281533

Symbol
  • KAP5-8
  • KAP5.2
  • KRTAP5-8
  • KRTAP5.2
  • KRTAP5.8
  • KRTAP5-8
  • KRTAP5.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.69
cell type or tissue
0.61
tissue
0.46
microRNA
0.45
tissue sample
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.15   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.15   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
KRTAP5-4
Tdark
Novelty:  0.40323321
Score:  0.824
Data Source:  STRINGDB
TACSTD2
Tclin
Novelty:  0.00297704
Score:  0.75
Data Source:  STRINGDB
KRTAP5-1
Tdark
Novelty:  0.83665339
Score:  0.714
Data Source:  STRINGDB
MACO1
Tbio
Novelty:  0.18252972
Score:  0.711
Data Source:  STRINGDB
KRTAP5-7
Tdark
Novelty:  3.45402383
Score:  0.644
Data Source:  STRINGDB
KRTAP4-2
Tdark
Novelty:  0.63177537
Score:  0.553
Data Source:  STRINGDB
C2orf66
Tdark
Novelty:  27.31034483
Score:  0.544
Data Source:  STRINGDB
KRTAP4-5
Tbio
Novelty:  3.61629007
Score:  0.543
Data Source:  STRINGDB
KRTAP5-9
Tdark
Novelty:  0.13336736
Score:  0.538
Data Source:  STRINGDB
CCDC190
Tdark
Novelty:  3.31387987
Score:  0.529
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin D measurement
1
2
2
90.1
cathepsin D measurement
1
2
2
90.1
cathepsin D measurement
1
2
2
90.1
hematocrit
1
1
1
15.5
hematocrit
1
1
1
15.5
Items per page:
1 – 5 of 15
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin D measurement
2
90.1
cathepsin D measurement
2
90.1
cathepsin D measurement
2
90.1
hematocrit
1
15.5
hematocrit
1
15.5
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 0.15
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title