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Tdark
KRTAP4-1
Keratin-associated protein 4-1

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398472
  • ENSP00000381489
  • ENSG00000198443

Symbol
  • KAP4.10
  • KRTAP4-10
  • KRTAP4.1
  • KRTAP4.10
  • KAP4.1
  • KAP4.10
  • KRTAP4-10
  • KRTAP4.10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.51
tissue sample
0.51
cell line
0.47
transcription factor
0.34
microRNA
0.32


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.13   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.13   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
KRTAP3-1
Tdark
Novelty:  1.73340145
Score:  0.619
Data Source:  STRINGDB
KRTAP26-1
Tdark
Novelty:  0.48053029
Score:  0.615
Data Source:  STRINGDB
KRTAP7-1
Tdark
Novelty:  0.31372157
Score:  0.595
Data Source:  STRINGDB
KRTAP11-1
Tbio
Novelty:  0.20865014
Score:  0.583
Data Source:  STRINGDB
KRTAP22-1
Tdark
Novelty:  0.75498951
Score:  0.574
Data Source:  STRINGDB
KRTAP3-3
Tdark
Novelty:  1.72994972
Score:  0.573
Data Source:  STRINGDB
KRTAP17-1
Tdark
Novelty:  2.798404
Score:  0.573
Data Source:  STRINGDB
KRTAP3-2
Tdark
Novelty:  1.99836821
Score:  0.571
Data Source:  STRINGDB
KRTAP6-3
Tdark
Novelty:  0.28055117
Score:  0.571
Data Source:  STRINGDB
KRTAP24-1
Tdark
Novelty:  0.3470695
Score:  0.568
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
44.5
gut microbiome measurement
2
1
2
6.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
44.5
gut microbiome measurement
2
6.8
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 0.13
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title