You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
KRTAP27-1
Keratin-associated protein 27-1

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382835
  • ENSP00000372286
  • ENSG00000206107

Symbol
  • KAP27.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.39
tissue
0.39
cell line
0.37
transcription factor
0.32
protein domain
0.15


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.2   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.2   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (104)
KRTAP25-1
Tdark
Novelty:  3.06713781
Score:  0.688
Data Source:  STRINGDB
KRTAP26-1
Tdark
Novelty:  0.48053029
Score:  0.661
Data Source:  STRINGDB
KRTAP24-1
Tdark
Novelty:  0.3470695
Score:  0.609
Data Source:  STRINGDB
KRTAP6-3
Tdark
Novelty:  0.28055117
Score:  0.602
Data Source:  STRINGDB
KRTAP19-4
Tdark
Novelty:  217
Score:  0.589
Data Source:  STRINGDB
KRTAP13-3
Tdark
Novelty:  0.50342897
Score:  0.573
Data Source:  STRINGDB
KRTAP23-1
Tdark
Novelty:  217
Score:  0.572
Data Source:  STRINGDB
KRTAP9-1
Tdark
Novelty:  2.40077493
Score:  0.571
Data Source:  STRINGDB
KRTAP10-8
Tdark
Novelty:  6.35380236
Score:  0.57
Data Source:  STRINGDB
KRTAP4-5
Tbio
Novelty:  3.61629007
Score:  0.567
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin associated protein 27-1
VGNC:1144
470066
Mouse
MGI:3646229
239933
Rat
RGD:2320648
100364613
Dog
keratin associated protein 27-1
VGNC:42541
487723
Horse
keratin associated protein 27-1
VGNC:19547
100065280
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin associated protein 27-1
Mouse
Rat
Dog
keratin associated protein 27-1
Horse
keratin associated protein 27-1
Publication Statistics
PubMed Score 1.20
PubMed score by year
Related Publications
No publications found