You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
KRTAP22-1
Keratin-associated protein 22-1

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334680
  • ENSP00000333887
  • ENSG00000186924

Symbol
  • KAP22.1
  • KAP22.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.35
phenotype
0.32
tissue
0.26
cellular component
0.23
disease
0.22


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.42   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.42   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
KRTAP6-3
Tdark
Novelty:  0.28055117
Score:  0.703
Data Source:  STRINGDB
KRTAP13-3
Tdark
Novelty:  0.50342897
Score:  0.699
Data Source:  STRINGDB
KRTAP6-2
Tdark
Novelty:  1.37501842
Score:  0.688
Data Source:  STRINGDB
KRTAP15-1
Tdark
Novelty:  1.11971653
Score:  0.68
Data Source:  STRINGDB
KRTAP24-1
Tdark
Novelty:  0.3470695
Score:  0.679
Data Source:  STRINGDB
KRTAP11-1
Tbio
Novelty:  0.20865014
Score:  0.658
Data Source:  STRINGDB
KRTAP23-1
Tdark
Novelty:  217
Score:  0.651
Data Source:  STRINGDB
KRTAP7-1
Tdark
Novelty:  0.31372157
Score:  0.641
Data Source:  STRINGDB
KRTAP5-4
Tdark
Novelty:  0.40323321
Score:  0.641
Data Source:  STRINGDB
KRTAP20-1
Tdark
Novelty:  0.5308345
Score:  0.639
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 1.42
PubMed score by year
PubTator Score 1.33
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title