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Tbio
KRTAP11-1
Keratin-associated protein 11-1

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332378
  • ENSP00000330720
  • ENSG00000182591

Symbol
  • KAP11.1
  • KRTAP11.1
  • HACL1
  • HACL-1
  • KAP11.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.42
tissue sample
0.36
gene perturbation
0.34
biological term
0.33
transcription factor
0.33


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.13   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.13   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
KRTAP24-1
Tdark
Novelty:  0.3470695
Score:  0.798
Data Source:  STRINGDB
KRTAP7-1
Tdark
Novelty:  0.31372157
Score:  0.794
Data Source:  STRINGDB
KRTAP8-1
Tbio
Novelty:  0.18211237
Score:  0.792
Data Source:  STRINGDB
KRTAP15-1
Tdark
Novelty:  1.11971653
Score:  0.749
Data Source:  STRINGDB
KRTAP13-3
Tdark
Novelty:  0.50342897
Score:  0.729
Data Source:  STRINGDB
KRTAP12-1
Tdark
Novelty:  0.59243755
Score:  0.704
Data Source:  STRINGDB
KRTAP6-2
Tdark
Novelty:  1.37501842
Score:  0.688
Data Source:  STRINGDB
KRTAP1-1
Tdark
Novelty:  0.00899174
Score:  0.666
Data Source:  STRINGDB
KRTAP22-1
Tdark
Novelty:  0.75498951
Score:  0.658
Data Source:  STRINGDB
KRTAP6-3
Tdark
Novelty:  0.28055117
Score:  0.645
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.6
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.6
4.5
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin associated protein 11-1
VGNC:1147
470070
Mouse
MGI:99447
16693
Rat
RGD:2323257
100359886
Dog
keratin associated protein 11-1
VGNC:42538
100687916
Horse
keratin associated protein 11-1
VGNC:19544
100064470
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin associated protein 11-1
Mouse
Rat
Dog
keratin associated protein 11-1
Horse
keratin associated protein 11-1
Publication Statistics
PubMed Score 6.13
PubMed score by year
PubTator Score 1.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title