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Tbio
KRT6C
Keratin, type II cytoskeletal 6C

Protein Summary
Description
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252250
  • ENSP00000252250
  • ENSG00000170465

Symbol
  • KRT6E
  • K6E
  • KRT6E
  • PPKNEFD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.85
cellular component
0.53
cell line
0.46
tissue
0.43
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.98   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.98   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
KRT16
Tbio
Novelty:  0.00503235
Score:  0.956
Data Source:  STRINGDB
KRT14
Tbio
Novelty:  0.00088743
Score:  0.956
Data Source:  STRINGDB
KRT6A
Tbio
Novelty:  0.00789111
Score:  0.952
Data Source:  STRINGDB
KRT6B
Tbio
Novelty:  0.00152754
Score:  0.95
Data Source:  STRINGDB
KRT17
Tbio
Novelty:  0.00278761
Score:  0.939
Data Source:  STRINGDB
KRT15
Tbio
Novelty:  0.00351898
Score:  0.935
Data Source:  STRINGDB
KRT13
Tbio
Novelty:  0.00468754
Score:  0.933
Data Source:  STRINGDB
KRT5
Tbio
Novelty:  0.00072336
Score:  0.932
Data Source:  STRINGDB
KRT9
Tbio
Novelty:  0.00787691
Score:  0.93
Data Source:  STRINGDB
KRT38
Tdark
Novelty:  0.25061021
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
keratinocyte carcinoma
1
2
0
1.1
90.6
4
1
1
1.2
81.2
balding measurement
1
2
2
72.5
non-melanoma skin carcinoma
1
1
0
1.3
54.4
cutaneous squamous cell carcinoma
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
keratinocyte carcinoma
0
1.1
90.6
1
1.2
81.2
balding measurement
2
72.5
non-melanoma skin carcinoma
0
1.3
54.4
cutaneous squamous cell carcinoma
1
5.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 7.98
PubMed score by year
PubTator Score 12.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title