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Tbio
KRT18
Keratin, type I cytoskeletal 18

Protein Summary
Description
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388835
  • ENSP00000373487
  • ENSG00000111057
  • ENST00000388837
  • ENSP00000373489

Symbol
  • CYK18
  • K18
  • CK-18
  • CYK18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
interacting protein
0.99
kinase perturbation
0.98
transcription factor perturbation
0.98
gene perturbation
0.97


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1408.27   (req: < 5)
Gene RIFs: 164   (req: <= 3)
Antibodies: 3147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1408.27   (req: >= 5)
Gene RIFs: 164   (req: > 3)
Antibodies: 3147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (179)
KRT8
Tbio
Novelty:  0.00093008
Score:  0.997
Data Source:  STRINGDB
KRT5
Tbio
Novelty:  0.00072336
Score:  0.962
Data Source:  STRINGDB
KRT19
Tbio
Novelty:  0.00043162
Score:  0.956
Data Source:  STRINGDB
KRT7
Tbio
Novelty:  0.00039796
Score:  0.956
Data Source:  STRINGDB
CASP6
Tchem
Family:  Enzyme
Novelty:  0.00234346
Score:  0.947
Data Source:  STRINGDB
KRT6A
Tbio
Novelty:  0.00789111
Score:  0.935
Data Source:  STRINGDB
KRT4
Tbio
Novelty:  0.00434637
Score:  0.935
Data Source:  STRINGDB
KRT3
Tbio
Novelty:  0.00489796
Score:  0.934
Data Source:  STRINGDB
KRT72
Tbio
Novelty:  0.06391566
Score:  0.933
Data Source:  STRINGDB
KRT76
Tdark
Novelty:  0.87892674
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
0
1.2
91.1
1
1
0
1.6
59.5
mean reticulocyte volume
1
1
1
33.1
body height
1
1
1
27.2
serum alanine aminotransferase measurement
1
1
0
5.7
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
91.1
0
1.6
59.5
mean reticulocyte volume
1
33.1
body height
1
27.2
serum alanine aminotransferase measurement
0
5.7
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 18
VGNC:8448
451923
Mouse
MGI:96692
16668
Rat
RGD:619935
294853
Dog
keratin 18
477601
Horse
keratin 18
100063542
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 18
Mouse
Rat
Dog
keratin 18
Horse
keratin 18
Publication Statistics
PubMed Score 1408.27
PubMed score by year
PubTator Score 1086.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title