Tbio KRT16 Keratin, type I cytoskeletal 16

Protein Summary

Description

Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P08779
• A8K488
• P30654
• Q16402
• Q9UBG8

Gene Name

• KRT16

Ensembl ID

• ENST00000301653
• ENSP00000301653
• ENSG00000186832

Symbol

• KRT16A
• K16
• PC1
• CK16
• K1CP
• NEPPK
• FNEPPK
• KRT16A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
gene perturbation	0.99
PubMedID	0.85
cellular component	0.76
disease	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.55   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 526   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.55   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0