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Tbio
KRT16
Keratin, type I cytoskeletal 16

Protein Summary
Description
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301653
  • ENSP00000301653
  • ENSG00000186832

Symbol
  • KRT16A
  • K16
  • PC1
  • CK16
  • K1CP
  • NEPPK
  • FNEPPK
  • KRT16A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
gene perturbation
0.99
PubMedID
0.85
cellular component
0.76
disease
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.55   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 526   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.55   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
KRT5
Tbio
Novelty:  0.00072336
Score:  0.996
Data Source:  STRINGDB
KRT10
Tbio
Novelty:  0.00166073
Score:  0.988
Data Source:  STRINGDB
KRT6B
Tbio
Novelty:  0.00152754
Score:  0.977
Data Source:  STRINGDB
KRT6A
Tbio
Novelty:  0.00789111
Score:  0.97
Data Source:  STRINGDB
KRT17
Tbio
Novelty:  0.00278761
Score:  0.967
Data Source:  STRINGDB
KRT14
Tbio
Novelty:  0.00088743
Score:  0.967
Data Source:  STRINGDB
KRT6C
Tbio
Novelty:  0.11659743
Score:  0.956
Data Source:  STRINGDB
KRT1
Tbio
Novelty:  0.00278467
Score:  0.949
Data Source:  STRINGDB
KRT82
Tdark
Novelty:  0.5488139
Score:  0.947
Data Source:  STRINGDB
KRT4
Tbio
Novelty:  0.00434637
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 16
VGNC:9353
100240746
Macaque
keratin 16
707236
Mouse
MGI:96690
16666
Rat
RGD:1590901
303530
Horse
keratin, type I cytoskeletal 16
100066610
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 16
Macaque
keratin 16
Mouse
Rat
Horse
keratin, type I cytoskeletal 16
Publication Statistics
PubMed Score 218.55
PubMed score by year
PubTator Score 231.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title