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Tbio
KRT15
Keratin, type I cytoskeletal 15

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254043
  • ENSP00000254043
  • ENSG00000171346
  • ENST00000393976
  • ENSP00000377546

Symbol
  • KRTB
  • K15
  • CK15
  • K1CO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
small molecule perturbation
0.81
interacting protein
0.74
cell type or tissue
0.71
disease
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 269.66   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 816   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 269.66   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 816   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
KRT5
Tbio
Novelty:  0.00072336
Score:  0.956
Data Source:  STRINGDB
KRT13
Tbio
Novelty:  0.00468754
Score:  0.952
Data Source:  STRINGDB
KRT1
Tbio
Novelty:  0.00278467
Score:  0.947
Data Source:  STRINGDB
KRT6B
Tbio
Novelty:  0.00152754
Score:  0.944
Data Source:  STRINGDB
KRT6A
Tbio
Novelty:  0.00789111
Score:  0.941
Data Source:  STRINGDB
KRT4
Tbio
Novelty:  0.00434637
Score:  0.94
Data Source:  STRINGDB
KRT80
Tbio
Novelty:  0.08480792
Score:  0.938
Data Source:  STRINGDB
KRT8
Tbio
Novelty:  0.00093008
Score:  0.936
Data Source:  STRINGDB
KRT6C
Tbio
Novelty:  0.11659743
Score:  0.935
Data Source:  STRINGDB
KRT7
Tbio
Novelty:  0.00039796
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 15
VGNC:9352
100611264
Mouse
MGI:96689
16665
Rat
RGD:1303044
287700
Dog
keratin 15
VGNC:42518
100685404
Cow
keratin 15
VGNC:50396
507464
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 15
Mouse
Rat
Dog
keratin 15
Cow
keratin 15
Publication Statistics
PubMed Score 269.66
PubMed score by year
PubTator Score 169.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title