Tbio KRT15 Keratin, type I cytoskeletal 15

Protein Summary

Description

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P19012
• B3KQY1
• B3KRA2
• E0CX14
• Q53XV8
• Q9BUG4

Gene Name

• KRT15

Ensembl ID

• ENST00000254043
• ENSP00000254043
• ENSG00000171346
• ENST00000393976
• ENSP00000377546

Symbol

• KRTB
• K15
• CK15
• K1CO

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
small molecule perturbation	0.81
interacting protein	0.74
cell type or tissue	0.71
disease	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.31   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 816   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.31   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 816   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0