Tbio KREMEN1 Kremen protein 1

Protein Summary

Description

Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96MU8
• B0QY46
• B0QY47
• B1AJR5
• Q5TIB9
• Q6P3X6
• Q9BY70
• Q9UGS5
• Q9UGU1

Gene Name

• KREMEN1

Ensembl ID

• ENST00000327813
• ENSP00000331242
• ENSG00000183762
• ENST00000400335
• ENSP00000383189
• ENST00000407188
• ENSP00000385431

Symbol

• KREMEN
• KRM1
• KRM1
• ECTD13
• KREMEN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.92
protein domain	0.85
histone modification site profile	0.84
kinase perturbation	0.84
tissue sample	0.63

Protein Classes

PANTHER Classes

Protein / Receptor / Kremen Protein 1

DTO Classes

Protein / Receptor / Kremen Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.25   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 311   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.25   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0