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Tclin
KRAS
GTPase KRas

Protein Summary
Description
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256078
  • ENSP00000256078
  • ENSG00000133703
  • ENST00000311936
  • ENSP00000308495

Symbol
  • KRAS2
  • RASK2
  • NS
  • NS3
  • CFC2
  • RALD
  • K-Ras
  • KRAS1
  • KRAS2
  • RASK2
  • KI-RAS
  • C-K-RAS
  • K-RAS2A
  • K-RAS2B
  • K-RAS4A
  • K-RAS4B
  • c-Ki-ras2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
disease
0.99
kinase perturbation
0.99
phenotype
0.98
transcription factor perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7489.18   (req: < 5)
Gene RIFs: 1937   (req: <= 3)
Antibodies: 754   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7489.18   (req: >= 5)
Gene RIFs: 1937   (req: > 3)
Antibodies: 754   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 116
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (760)
RIN1
Tbio
Novelty:  0.02401084
p_int:  0.999999965
p_ni:  2e-9
p_wrong:  3.3e-8
Score:  0.956
Data Source:  BioPlex,STRINGDB
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.999983793
p_ni:  1.04e-7
p_wrong:  0.000016103
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
Score:  0.998
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.998
Data Source:  Reactome,STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.996
Data Source:  STRINGDB
RAF1
Tclin
Family:  Kinase
Novelty:  0.00117121
Score:  0.995
Data Source:  Reactome,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.995
Data Source:  STRINGDB
PIK3CG
Tclin
Family:  Kinase
Novelty:  0.00170533
Score:  0.993
Data Source:  STRINGDB
SOS1
Tchem
Novelty:  0.00285343
Score:  0.993
Data Source:  Reactome,STRINGDB
ERBB2
Tclin
Family:  Kinase
Novelty:  0.00003761
Score:  0.991
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (26)
Explore Nearest Tclin Targets
Pathways (373)
Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 129
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through FRS2 and FRS3
Reactome
Activated NTRK2 signals through RAS
Reactome
Activated NTRK3 signals through RAS
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of RAS in B cells
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through RAS
Activated NTRK3 signals through RAS
Activation of NMDA receptors and postsynaptic events
Activation of RAS in B cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (44)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
74.3
sex hormone-binding globulin measurement
6
1
6
42.1
testosterone measurement
1
1
1
21.3
low density lipoprotein cholesterol measurement
1
1
1
11.1
serum albumin measurement
1
1
1
10.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
74.3
sex hormone-binding globulin measurement
6
42.1
testosterone measurement
1
21.3
low density lipoprotein cholesterol measurement
1
11.1
serum albumin measurement
1
10.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
KRAS proto-oncogene, GTPase
707977
Mouse
MGI:96680
16653
Rat
RGD:2981
24525
Dog
KRAS proto-oncogene, GTPase
VGNC:42508
403871
Horse
KRAS proto-oncogene, GTPase
100064473
Species
Name
OMA
EggNOG
Inparanoid
Macaque
KRAS proto-oncogene, GTPase
Mouse
Rat
Dog
KRAS proto-oncogene, GTPase
Horse
KRAS proto-oncogene, GTPase
Publication Statistics
PubMed Score 7489.18
PubMed score by year
PubTator Score 8235.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title