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Tdark
KPRP
Keratinocyte proline-rich protein

Protein Summary
Description
This gene encodes a proline-rich skin protein possibly involved in keratinocyte differentiation. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000606109
  • ENSP00000475216
  • ENSG00000203786

Symbol
  • C1orf45
  • C1orf45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.47
metabolite
0.45
microRNA
0.44
protein complex
0.42
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
GDF5
Tbio
Novelty:  0.00218118
p_int:  0.995507467
p_ni:  0.004492533
Data Source:  BioPlex
B3GALNT1
Tbio
Family:  Enzyme
Novelty:  0.01235828
p_int:  0.99548986
p_ni:  0.00451014
Data Source:  BioPlex
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.993602375
p_ni:  0.006397625
Data Source:  BioPlex
CHCHD5
Tbio
Novelty:  0.16304141
p_int:  0.986858216
p_ni:  0.013141784
Data Source:  BioPlex
DTL
Tbio
Novelty:  0.01659105
p_int:  0.986286308
p_ni:  0.013713656
p_wrong:  3.7e-8
Data Source:  BioPlex
SLC22A23
Tbio
Family:  Transporter
Novelty:  0.23405744
p_int:  0.979173145
p_ni:  0.0208079
p_wrong:  0.000018955
Score:  0.175
Data Source:  BioPlex,STRINGDB
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.978218854
p_ni:  0.021771271
p_wrong:  0.000009875
Data Source:  BioPlex
EHF
Tbio
Family:  TF
Novelty:  0.00990018
p_int:  0.964431333
p_ni:  0.035540384
p_wrong:  0.000028284
Score:  0.241
Data Source:  BioPlex,STRINGDB
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.941261959
p_ni:  0.05873804
Data Source:  BioPlex
UBAC2
Tbio
Novelty:  0.13384376
p_int:  0.93942754
p_ni:  0.060562253
p_wrong:  0.000010207
Score:  0.198
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
1
2
2
61.3
2
3
0
1.2
59.9
1
1
0
1.2
28
1
1
0
1.1
24.4
COVID-19
1
1
0
1.3
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
61.3
0
1.2
59.9
0
1.2
28
0
1.1
24.4
COVID-19
0
1.3
1.6
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1920981
433619
Rat
RGD:1303244
432393
Horse
keratinocyte proline rich protein
VGNC:19511
106780866
Cow
keratinocyte proline rich protein
VGNC:30708
100140143
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
keratinocyte proline rich protein
Cow
keratinocyte proline rich protein
Publication Statistics
PubMed Score 9.22
PubMed score by year
PubTator Score 2.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title