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Tbio
KPNA6
Importin subunit alpha-7

Protein Summary
Description
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373625
  • ENSP00000362728
  • ENSG00000025800

Symbol
  • IPOA7
  • IPOA7
  • KPNA7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
microRNA
0.76
transcription factor perturbation
0.74
protein domain
0.73
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.73   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.73   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
RNMT
Tbio
Family:  Enzyme
Novelty:  0.00880207
p_int:  0.99281409
p_ni:  0.00718591
Score:  0.338
Data Source:  BioPlex,STRINGDB
NOP56
Tbio
Novelty:  0.01256937
p_int:  0.942424639
p_ni:  0.057575361
Score:  0.529
Data Source:  BioPlex,STRINGDB
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.928461044
p_ni:  0.071538956
Score:  0.158
Data Source:  BioPlex,STRINGDB
SREK1IP1
Tdark
Novelty:  1.39429464
p_int:  0.877631241
p_ni:  0.122368759
Score:  0.16
Data Source:  BioPlex,STRINGDB
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.862523603
p_ni:  0.137476397
Score:  0.542
Data Source:  BioPlex,STRINGDB
KBTBD4
Tdark
Novelty:  0.35515885
p_int:  0.860506233
p_ni:  0.139493767
Score:  0.206
Data Source:  BioPlex,STRINGDB
SURF2
Tdark
Novelty:  0.10662558
p_int:  0.851103686
p_ni:  0.148896314
Score:  0.207
Data Source:  BioPlex,STRINGDB
LMNA
Tbio
Novelty:  0.00046972
p_int:  0.848269915
p_ni:  0.151730085
Score:  0.421
Data Source:  BioPlex,STRINGDB
KPNB1
Tbio
Novelty:  0.01469696
Score:  0.963
Data Source:  STRINGDB
RCC1
Tbio
Novelty:  0.00260884
Score:  0.887
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
1
1
0
3.8
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
0
3.8
17.8
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit alpha 6
VGNC:6900
456709
Macaque
karyopherin subunit alpha 6
706812
Mouse
MGI:1100836
16650
Rat
RGD:1306570
362607
Dog
karyopherin subunit alpha 6
VGNC:42504
487314
Species
Name
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit alpha 6
Macaque
karyopherin subunit alpha 6
Mouse
Rat
Dog
karyopherin subunit alpha 6
Publication Statistics
PubMed Score 30.73
PubMed score by year
PubTator Score 4.83
PubTator score by year
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Related Publications
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PMID
Year
Title