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Tbio
KPNA2
Importin subunit alpha-1

Protein Summary
Description
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330459
  • ENSP00000332455
  • ENSG00000182481
  • ENST00000537025
  • ENSP00000438483

Symbol
  • RCH1
  • SRP1
  • QIP2
  • RCH1
  • IPOA1
  • SRP1alpha
  • SRP1-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
viral protein
1
virus
0.98
kinase perturbation
0.96
histone modification site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.96   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.96   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (330)
CDCA2
Tbio
Novelty:  0.04666018
p_int:  0.999995601
p_ni:  0.000004399
Score:  0.82
Data Source:  BioPlex,STRINGDB
NUP153
Tbio
Novelty:  0.00696568
p_int:  0.998310668
p_ni:  0.001689332
Score:  0.994
Data Source:  BioPlex,STRINGDB
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.959435993
p_ni:  0.040564007
Score:  0.858
Data Source:  BioPlex,STRINGDB
KPNB1
Tbio
Novelty:  0.01469696
p_int:  0.952895149
p_ni:  0.047104851
Score:  0.999
Data Source:  BioPlex,STRINGDB
RAB39B
Tbio
Family:  Enzyme
Novelty:  0.02362498
p_int:  0.951215612
p_ni:  0.048784388
Score:  0.252
Data Source:  BioPlex,STRINGDB
RGPD5
Tbio
Novelty:  0.13776125
p_int:  0.894087608
p_ni:  0.105912392
Score:  0.407
Data Source:  BioPlex,STRINGDB
TPX2
Tbio
Novelty:  0.00435921
Score:  0.992
Data Source:  STRINGDB
RCC1
Tbio
Novelty:  0.00260884
Score:  0.991
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.982
Data Source:  STRINGDB
RANBP1
Tbio
Family:  Enzyme
Novelty:  0.01208948
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (41)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Reactome
Ca-dependent events
Reactome
CaM pathway
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Antiviral mechanism by IFN-stimulated genes
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ca-dependent events
CaM pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
82.9
eosinophil percentage of leukocytes
2
2
2
80.5
body mass index
3
2
3
70.4
eosinophil percentage of granulocytes
1
1
1
68
waist-hip ratio
2
1
2
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
82.9
eosinophil percentage of leukocytes
2
80.5
body mass index
3
70.4
eosinophil percentage of granulocytes
1
68
waist-hip ratio
2
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit alpha 2
100612155
Macaque
karyopherin subunit alpha 2
100430009
Mouse
MGI:103561
16647
Mouse
MGI:3704480
100043906
Rat
RGD:621419
85245
Species
Name
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit alpha 2
Macaque
karyopherin subunit alpha 2
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 226.96
PubMed score by year
PubTator Score 85.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title