Tbio KPNA2 Importin subunit alpha-1

Protein Summary

Description

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• P52292
• B9EJD6
• Q53YE3
• Q6NVW7
• Q9BRU5

Gene Name

• KPNA2

Ensembl ID

• ENST00000330459
• ENSP00000332455
• ENSG00000182481
• ENST00000537025
• ENSP00000438483

Symbol

• RCH1
• SRP1
• QIP2
• RCH1
• IPOA1
• SRP1alpha
• SRP1-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
viral protein	1
virus	0.98
kinase perturbation	0.96
histone modification site profile	0.84

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Importin Subunit Alpha-1

DTO Classes

Protein / Transporter / Importin Subunit Alpha-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.96   (req: < 5)

Gene RIFs: 137   (req: <= 3)

Antibodies: 393   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.96   (req: >= 5)

Gene RIFs: 137   (req: > 3)

Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0