You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KNTC1
Kinetochore-associated protein 1

Protein Summary
Description
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333479
  • ENSP00000328236
  • ENSG00000184445

Symbol
  • KIAA0166
  • ROD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor binding site profile
0.86
interacting protein
0.84
transcription factor perturbation
0.84
cellular component
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.34   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.34   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (277)
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.999816781
p_ni:  0.000183219
Data Source:  BioPlex
C12orf49
Tdark
Novelty:  0.56030929
p_int:  0.995829205
p_ni:  0.004170795
Score:  0.186
Data Source:  BioPlex,STRINGDB
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.994920945
p_ni:  0.005079055
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.99029617
p_ni:  0.00970383
Data Source:  BioPlex
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.968401
p_ni:  0.031599
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.951395109
p_ni:  0.048604887
p_wrong:  4e-9
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.951289959
p_ni:  0.048710039
p_wrong:  2e-9
Data Source:  BioPlex
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.939798073
p_ni:  0.060201387
p_wrong:  5.4e-7
Data Source:  BioPlex
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.938044202
p_ni:  0.061954624
p_wrong:  0.000001173
Data Source:  BioPlex
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
p_int:  0.933788686
p_ni:  0.066211314
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
16
16
97.4
waist-hip ratio
1
15
15
97.4
high density lipoprotein cholesterol measurement
3
5
5
97.3
waist circumference
1
11
11
94.2
body mass index
4
3
4
92.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
16
97.4
waist-hip ratio
15
97.4
high density lipoprotein cholesterol measurement
5
97.3
waist circumference
11
94.2
body mass index
4
92.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinetochore associated 1
VGNC:5444
452329
Macaque
kinetochore associated 1
702579
Mouse
MGI:2673709
208628
Rat
RGD:1307905
304477
Dog
kinetochore associated 1
VGNC:42499
486254
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinetochore associated 1
Macaque
kinetochore associated 1
Mouse
Rat
Dog
kinetochore associated 1
Publication Statistics
PubMed Score 13.34
PubMed score by year
PubTator Score 21.86
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title