Tbio KNSTRN Small kinetochore-associated protein

Protein Summary

Description

Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).

Uniprot Accession IDs

• Q9Y448
• B4DXA7
• Q147U5
• Q32Q57
• Q5ISJ0
• Q6P2S5
• Q6PJM0
• Q86XB4
• SKAP

Gene Name

• KNSTRN

Ensembl ID

• ENST00000249776
• ENSP00000249776
• ENSG00000128944
• ENST00000416151
• ENSP00000391233
• ENST00000448395
• ENSP00000393001

Symbol

• C15orf23
• SKAP
• TRAF4AF1
• SKAP
• HSD11
• C15orf23
• TRAF4AF1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
cellular component	0.76
kinase perturbation	0.76
protein complex	0.76
tissue sample	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.36   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 45   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.36   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (122)

Explore Interacting Targets

1 – 10 of 122

• See Interactions on String-DB

PRPF19

Tbio

Novelty:  0.01616737

p_int:  0.999999944

p_ni:  5.5e-8

Score:  0.603

Data Source:  BioPlex,STRINGDB

MYCBP

Tbio

Novelty:  0.03202836

p_int:  0.999898033

p_ni:  0.000101208

p_wrong:  7.59e-7

Score:  0.43

Data Source:  BioPlex,STRINGDB

SGF29

Tbio

Family:  Epigenetic

Novelty:  0.0426456

p_int:  0.999810905

p_ni:  0.000189092

p_wrong:  3e-9

Data Source:  BioPlex

SSSCA1

Tdark

Novelty:  0.53523038

p_int:  0.999809592

p_ni:  0.000190407

p_wrong:  1e-9

Data Source:  BioPlex

BORCS6

Tdark

Novelty:  0.83789033

p_int:  0.999451608

p_ni:  0.000548381

p_wrong:  1.1e-8

Score:  0.16

Data Source:  BioPlex,STRINGDB

USB1

Tbio

Family:  Enzyme

Novelty:  0.01677996

p_int:  0.996285854

p_ni:  0.003384225

p_wrong:  0.000329921

Score:  0.207

Data Source:  BioPlex,STRINGDB

TACC1

Tbio

Novelty:  0.03556945

p_int:  0.995818959

p_ni:  0.004180769

p_wrong:  2.72e-7

Score:  0.173

Data Source:  BioPlex,STRINGDB

CCDC89

Tdark

Novelty:  0.62754711

p_int:  0.995138555

p_ni:  0.004461689

p_wrong:  0.000399755

Score:  0.169

Data Source:  BioPlex,STRINGDB

IFT57

Tbio

Novelty:  0.03373199

p_int:  0.994586667

p_ni:  0.004210894

p_wrong:  0.001202439

Score:  0.282

Data Source:  BioPlex,STRINGDB

SYCE3

Tdark

Novelty:  0.22361224

p_int:  0.993361599

p_ni:  0.006637431

p_wrong:  9.69e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

WikiPathways (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Overview of leukocyte-intrinsic Hippo pathway functions	99 targets	WP4542_r104788

Name	Explore in Pharos	Explore in Source
Overview of leukocyte-intrinsic Hippo pathway functions	99 targets	WP4542_r104788

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Components (8)

Processes (5)

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10

1 – 8 of 8

GO Term	Evidence	Assigned by
cytosol	Inferred from Direct Assay (IDA)	HPA
kinetochore	Inferred from Direct Assay (IDA)	UniProtKB
microtubule cytoskeleton	Inferred from Direct Assay (IDA)	HPA
microtubule plus-end	Inferred from Direct Assay (IDA)	UniProtKB
mitotic spindle	Inferred from Direct Assay (IDA)	UniProtKB
condensed chromosome kinetochore	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
nucleus	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
spindle pole	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations (null)

No disease associations found

GWAS Traits (25)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 25

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	5	4	2	1.1	89.1
testosterone measurement	EFO_0004908	2	2	2		88
blood metabolite measurement	EFO_0005664	2	1	2		82.9
coronary artery disease	EFO_0001645	1	1	0	33.3	79.5
myocardial infarction	EFO_0000612	1	1	0	100	77.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 25

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	2	1.1	89.1
testosterone measurement	EFO_0004908	2		88
blood metabolite measurement	EFO_0005664	2		82.9
coronary artery disease	EFO_0001645	0	33.3	79.5
myocardial infarction	EFO_0000612	0	100	77.3

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell cycle
Cell division
Centromere
Chromosome
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
blood metabolite measurement
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
chronic kidney disease
cognitive function measurement
coronary artery disease
forced expiratory volume
high density lipoprotein cholesterol measurement
idiopathic pulmonary fibrosis

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	kinetochore localized astrin/SPAG5 binding protein		738257
Mouse	kinetochore-localized astrin/SPAG5 binding	MGI:1289298	51944
Rat	kinetochore-localized astrin/SPAG5 binding protein	RGD:1303240	311325
Dog	kinetochore localized astrin (SPAG5) binding protein	VGNC:42498	100856281
Horse	kinetochore localized astrin (SPAG5) binding protein	VGNC:19501	100071423

Species	Name	OMA	EggNOG	Inparanoid
Chimp	kinetochore localized astrin/SPAG5 binding protein
Mouse	kinetochore-localized astrin/SPAG5 binding
Rat	kinetochore-localized astrin/SPAG5 binding protein
Dog	kinetochore localized astrin (SPAG5) binding protein
Horse	kinetochore localized astrin (SPAG5) binding protein

Publication Statistics

PubMed Score 28.36

PubMed score by year

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PubTator Score 17.61

PubTator score by year

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Related Publications

Text Mined References (21)

GeneRif Annotations (12)

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10

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PMID	Year	Title