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Tbio
KNSTRN
Small kinetochore-associated protein

Protein Summary
Description
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249776
  • ENSP00000249776
  • ENSG00000128944
  • ENST00000416151
  • ENSP00000391233
  • ENST00000448395
  • ENSP00000393001

Symbol
  • C15orf23
  • SKAP
  • TRAF4AF1
  • SKAP
  • HSD11
  • C15orf23
  • TRAF4AF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
cellular component
0.76
kinase perturbation
0.76
protein complex
0.76
tissue sample
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.36   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.36   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.999999944
p_ni:  5.5e-8
Score:  0.603
Data Source:  BioPlex,STRINGDB
MYCBP
Tbio
Novelty:  0.03202836
p_int:  0.999898033
p_ni:  0.000101208
p_wrong:  7.59e-7
Score:  0.43
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999810905
p_ni:  0.000189092
p_wrong:  3e-9
Data Source:  BioPlex
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.999809592
p_ni:  0.000190407
p_wrong:  1e-9
Data Source:  BioPlex
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.999451608
p_ni:  0.000548381
p_wrong:  1.1e-8
Score:  0.16
Data Source:  BioPlex,STRINGDB
USB1
Tbio
Family:  Enzyme
Novelty:  0.01677996
p_int:  0.996285854
p_ni:  0.003384225
p_wrong:  0.000329921
Score:  0.207
Data Source:  BioPlex,STRINGDB
TACC1
Tbio
Novelty:  0.03556945
p_int:  0.995818959
p_ni:  0.004180769
p_wrong:  2.72e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
CCDC89
Tdark
Novelty:  0.62754711
p_int:  0.995138555
p_ni:  0.004461689
p_wrong:  0.000399755
Score:  0.169
Data Source:  BioPlex,STRINGDB
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.994586667
p_ni:  0.004210894
p_wrong:  0.001202439
Score:  0.282
Data Source:  BioPlex,STRINGDB
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.993361599
p_ni:  0.006637431
p_wrong:  9.69e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
2
1.1
89.1
testosterone measurement
2
2
2
88
blood metabolite measurement
2
1
2
82.9
1
1
0
33.3
79.5
1
1
0
100
77.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
89.1
testosterone measurement
2
88
blood metabolite measurement
2
82.9
0
33.3
79.5
0
100
77.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinetochore localized astrin/SPAG5 binding protein
738257
Mouse
MGI:1289298
51944
Rat
RGD:1303240
311325
Dog
kinetochore localized astrin (SPAG5) binding protein
VGNC:42498
100856281
Horse
kinetochore localized astrin (SPAG5) binding protein
VGNC:19501
100071423
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinetochore localized astrin/SPAG5 binding protein
Mouse
Rat
Dog
kinetochore localized astrin (SPAG5) binding protein
Horse
kinetochore localized astrin (SPAG5) binding protein
Publication Statistics
PubMed Score 28.36
PubMed score by year
PubTator Score 17.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title