Tbio KNSTRN Small kinetochore-associated protein

Protein Summary

Description

Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).

Uniprot Accession IDs

• Q9Y448
• B4DXA7
• Q147U5
• Q32Q57
• Q5ISJ0
• Q6P2S5
• Q6PJM0
• Q86XB4
• SKAP

Gene Name

• KNSTRN

Ensembl ID

• ENST00000249776
• ENSP00000249776
• ENSG00000128944
• ENST00000416151
• ENSP00000391233
• ENST00000448395
• ENSP00000393001

Symbol

• C15orf23
• SKAP
• TRAF4AF1
• SKAP
• HSD11
• C15orf23
• TRAF4AF1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
cellular component	0.76
kinase perturbation	0.76
protein complex	0.76
tissue sample	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.79   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 45   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.79   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0