Protein Summary
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood c ...more
- ENST00000265023
- ENSP00000265023
- ENSG00000113889
- ENST00000287611
- ENSP00000287611
- ENST00000447445
- ENSP00000396025
- ENST00000644859
- ENSP00000493985
- ENST00000645909
- ENSP00000496167
- BDK
- KNG
- BK
- BDK
- KNG
- HMWK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.88 | ||
chemical | 0.83 | ||
virus perturbation | 0.83 | ||
co-expressed gene | 0.76 | ||
molecular function | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12644.01 (req: < 5)
Gene RIFs: 75 (req: <= 3)
Antibodies: 673 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12644.01 (req: >= 5)
Gene RIFs: 75 (req: > 3)
Antibodies: 673 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (698)
CTSO
Family: Enzyme
Novelty: 0.09963965
p_int: 0.999990261
p_ni: 0.000009734
p_wrong: 5e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
GDPD1
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999435407
p_ni: 0.000564271
p_wrong: 3.22e-7
Data Source: BioPlex
CAPN1
Novelty: 0.00252811
p_int: 0.999234184
p_ni: 0.000765816
Score: 0.509
Data Source: BioPlex,STRINGDB
ANAPC1
Family: Enzyme
Novelty: 0.0521845
p_int: 0.998921108
p_ni: 0.001078892
Score: 0.183
Data Source: BioPlex,STRINGDB
P3H3
Family: Enzyme
Novelty: 0.0010004
p_int: 0.994106249
p_ni: 0.005893751
Score: 0.17
Data Source: BioPlex,STRINGDB
CTSV
Family: Enzyme
Novelty: 0.00916301
p_int: 0.989946728
p_ni: 0.010053272
Score: 0.564
Data Source: BioPlex,STRINGDB
VHL
Family: Enzyme
Novelty: 0.00285782
p_int: 0.985073491
p_ni: 0.014926243
p_wrong: 2.66e-7
Data Source: BioPlex
PPP2R2C
Family: Enzyme
Novelty: 0.05453128
p_int: 0.985011144
p_ni: 0.002364233
p_wrong: 0.012624623
Data Source: BioPlex
ZNF562
Family: TF
Novelty: 12.38372093
p_int: 0.977562749
p_ni: 0.022434957
p_wrong: 0.000002293
Score: 0.161
Data Source: BioPlex,STRINGDB
ANAPC5
Family: Enzyme
Novelty: 0.02102572
p_int: 0.962820952
p_ni: 0.037179048
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (82)
Reactome (18)
KEGG (9)
PathwayCommons (9)
WikiPathways (46)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
G alpha (i) signalling events | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (4)
Components (8)
Processes (15)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
adiponectin measurement | 4 | 5 | 5 | 96.5 | |||||
partial thromboplastin time | 2 | 3 | 3 | 95.7 | |||||
glomerular filtration rate | 7 | 5 | 6 | 8.1 | 92 | ||||
factor XI measurement | 1 | 1 | 1 | 88.4 | |||||
BMI-adjusted adiponectin measurement | 1 | 2 | 2 | 85.9 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
adiponectin measurement | 5 | 96.5 | |||||
partial thromboplastin time | 3 | 95.7 | |||||
glomerular filtration rate | 6 | 8.1 | 92 | ||||
factor XI measurement | 1 | 88.4 | |||||
BMI-adjusted adiponectin measurement | 2 | 85.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | kininogen 1 | VGNC:1858 | 460916 | |||||
Macaque | kininogen 1 | 707466 | ||||||
Mouse | MGI:3027157 | 385643 | ||||||
Dog | kininogen 1 | VGNC:53466 | 478666 | |||||
Horse | kininogen 1 | VGNC:19498 | 100068133 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | kininogen 1 | |||||
Macaque | kininogen 1 | |||||
Mouse | ||||||
Dog | kininogen 1 | |||||
Horse | kininogen 1 | |||||
Publication Statistics
PubMed Score 12644.01
PubMed score by year
PubTator Score 4971.59
PubTator score by year
Related Publications
Text Mined References (162)
GeneRif Annotations (75)
Items per page:
0 of 0
PMID | Year | Title |
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