Tchem KMT5B Histone-lysine N-methyltransferase KMT5B

Protein Summary

Description

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q4FZB7
• B7WNX7
• Q3SX56
• Q4V775
• Q6P150
• Q96E44
• Q9BUL0
• Q9H022
• Q9H2K3
• Q9NXV3
• Q9Y393

Gene Name

• KMT5B

Ensembl ID

• ENST00000304363
• ENSP00000305899
• ENSG00000110066
• ENST00000401547
• ENSP00000385965
• ENST00000405515
• ENSP00000385640
• ENST00000615954
• ENSP00000484858

Symbol

• SUV420H1
• CGI85
• MRD51
• CGI-85
• SUV420H1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Writer / Protein Methyltransferase / Histone-lysine N-methyltransferase Kmt5b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.69   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 225   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.69   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0