You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
KMT5A
N-lysine methyltransferase KMT5A

Protein Summary
Description
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The enco ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402868
  • ENSP00000384629
  • ENSG00000183955

Symbol
  • PRSET7
  • SET07
  • SET8
  • SETD8
  • SET8
  • SET07
  • SETD8
  • PR-Set7
  • PR/SET07
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.66   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 539   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.66   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 539   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (163)
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.993
Data Source:  Reactome,STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
Score:  0.976
Data Source:  Reactome,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
Score:  0.958
Data Source:  STRINGDB
H2AFV
Tbio
Novelty:  0.03561635
Score:  0.955
Data Source:  STRINGDB
HIST2H2BE
Tbio
Novelty:  0.00024381
Score:  0.949
Data Source:  STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.945
Data Source:  STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
Score:  0.941
Data Source:  STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
Score:  0.94
Data Source:  STRINGDB
HIST3H3
Tbio
Novelty:  0.04915012
Score:  0.934
Data Source:  STRINGDB
HIST1H2BK
Tbio
Novelty:  0.12867647
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Condensation of Prophase Chromosomes
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Chromatin modifying enzymes
Chromatin organization
Condensation of Prophase Chromosomes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
8
8
93.3
waist-hip ratio
1
7
7
93
high density lipoprotein cholesterol measurement
10
5
15
92.4
lymphocyte count
3
3
3
91.7
body height
2
2
2
89
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
8
93.3
waist-hip ratio
7
93
high density lipoprotein cholesterol measurement
15
92.4
lymphocyte count
3
91.7
body height
2
89
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
lysine methyltransferase 5A
709345
Mouse
MGI:1915206
67956
Rat
RGD:1587560
689820
Dog
lysine methyltransferase 5A
VGNC:42493
610615
Horse
lysine methyltransferase 5A
VGNC:19495
100060853
Species
Name
OMA
EggNOG
Inparanoid
Macaque
lysine methyltransferase 5A
Mouse
Rat
Dog
lysine methyltransferase 5A
Horse
lysine methyltransferase 5A
Publication Statistics
PubMed Score 126.66
PubMed score by year
PubTator Score 89.17
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title