Tbio KMT2E Inactive histone-lysine N-methyltransferase 2E

Protein Summary

Description

Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:24130829, PubMed:23798402). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:24130829, PubMed:23798402). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). Isoform NKp44L: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8IZD2
• B6ZDE4
• B6ZDM3
• M4K8J3
• Q6P5Y2
• Q6PKG4
• Q6T316
• Q86TI3
• Q86W12
• Q86WG0
• Q86WL2
• Q8IV78
• Q8IWR5
• Q8NFF8
• Q9NWE7
• Inactive lysine N-methyltransferase 2E

Gene Name

• KMT2E

Ensembl ID

• ENST00000257745
• ENSP00000257745
• ENSG00000005483
• ENST00000311117
• ENSP00000312379
• ENST00000334884
• ENSP00000335398
• ENST00000476671
• ENSP00000417888

Symbol

• MLL5
• MLL5
• NKp44L
• HDCMC04P

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.92
transcription factor binding site profile	0.92
small molecule perturbation	0.86
protein domain	0.85
transcription factor	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.91   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.91   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0