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Tbio
KMT2C
Histone-lysine N-methyltransferase 2C

Protein Summary
Description
Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262189
  • ENSP00000262189
  • ENSG00000055609
  • ENST00000355193
  • ENSP00000347325

Symbol
  • HALR
  • KIAA1506
  • MLL3
  • HALR
  • MLL3
  • KLEFS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.86
kinase perturbation
0.84
microRNA
0.77
transcription factor binding site profile
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.88   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.88   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (230)
WDR5
Tchem
Novelty:  0.0059945
Score:  0.995
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.994
Data Source:  STRINGDB
PAXIP1
Tbio
Novelty:  0.01728724
Score:  0.992
Data Source:  STRINGDB
RBBP5
Tbio
Novelty:  0.02221059
Score:  0.991
Data Source:  STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.99
Data Source:  STRINGDB
KDM6A
Tchem
Family:  Epigenetic
Novelty:  0.00267001
Score:  0.99
Data Source:  STRINGDB
KMT2A
Tchem
Family:  Epigenetic
Novelty:  0.00192554
Score:  0.988
Data Source:  STRINGDB
KMT2D
Tbio
Family:  Epigenetic
Novelty:  0.00380525
Score:  0.988
Data Source:  STRINGDB
NCOA6
Tbio
Novelty:  0.00750424
Score:  0.987
Data Source:  STRINGDB
DPY30
Tbio
Novelty:  0.03098629
Score:  0.986
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Chromatin modifying enzymes
Chromatin organization
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
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Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
20.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine methyltransferase 2C
VGNC:8696
463875
Mouse
MGI:2444959
231051
Dog
lysine methyltransferase 2C
VGNC:42490
611094
Cow
lysine methyltransferase 2C
VGNC:30692
789336
Platypus
lysine methyltransferase 2C [Source:HGNC Symbol;Acc:HGNC:13726]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine methyltransferase 2C
Mouse
Dog
lysine methyltransferase 2C
Cow
lysine methyltransferase 2C
Platypus
lysine methyltransferase 2C [Source:HGNC Symbol;Acc:HGNC:13726]
Publication Statistics
PubMed Score 203.88
PubMed score by year
PubTator Score 72.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title