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Tchem
KMT2A
Histone-lysine N-methyltransferase 2A

Protein Summary
Description
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation (PubMed:12453419, PubMed:20677832, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389506
  • ENSP00000374157
  • ENSG00000118058
  • ENST00000534358
  • ENSP00000436786
  • ENST00000649699
  • ENSP00000496927

Symbol
  • ALL1
  • CXXC7
  • HRX
  • HTRX
  • MLL
  • MLL1
  • TRX1
  • HRX
  • MLL
  • MLL1
  • TRX1
  • ALL-1
  • CXXC7
  • HTRX1
  • MLL1A
  • WDSTS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
1
molecular function
0.99
biological process
0.96
drug perturbation
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 568.2   (req: < 5)
Gene RIFs: 358   (req: <= 3)
Antibodies: 429   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 568.2   (req: >= 5)
Gene RIFs: 358   (req: > 3)
Antibodies: 429   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (259)
HCFC2
Tbio
Novelty:  0.12260416
p_int:  0.999999828
p_ni:  1.4e-7
p_wrong:  3.2e-8
Score:  0.834
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999998346
p_ni:  0.000001642
p_wrong:  1.2e-8
Score:  0.992
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999998045
p_ni:  0.000001955
Data Source:  BioPlex
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.9999576
p_ni:  0.000042399
p_wrong:  1e-9
Score:  0.233
Data Source:  BioPlex,STRINGDB
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.986706964
p_ni:  0.013293035
Score:  0.551
Data Source:  BioPlex,STRINGDB
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.982902062
p_ni:  0.017097937
p_wrong:  1e-9
Score:  0.547
Data Source:  BioPlex,STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.993
Data Source:  STRINGDB
RBBP5
Tbio
Novelty:  0.02221059
Score:  0.991
Data Source:  STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.99
Data Source:  STRINGDB
KMT2C
Tbio
Family:  Epigenetic
Novelty:  0.00689437
Score:  0.988
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
1.4
94.9
6
2
0
1.3
92.2
1
1
0
1.1
67.4
triglyceride measurement
2
1
2
64.4
hematocrit
2
2
2
64.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
94.9
0
1.3
92.2
0
1.1
67.4
triglyceride measurement
2
64.4
hematocrit
2
64.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine methyltransferase 2A
VGNC:7657
451587
Macaque
lysine methyltransferase 2A
705511
Mouse
MGI:96995
214162
Rat
RGD:1586165
315606
Dog
lysine methyltransferase 2A
VGNC:42489
479417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine methyltransferase 2A
Macaque
lysine methyltransferase 2A
Mouse
Rat
Dog
lysine methyltransferase 2A
Publication Statistics
PubMed Score 568.20
PubMed score by year
PubTator Score 1651.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title