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Tbio
KLRK1
NKG2-D type II integral membrane protein

Protein Summary
Description
Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. This locus represents natura ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240618
  • ENSP00000240618
  • ENSG00000213809
  • ENST00000540818
  • ENSP00000446003

Symbol
  • D12S2489E
  • NKG2D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
PubMedID
0.77
cell type or tissue
0.75
tissue sample
0.69
protein complex
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 898.5   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 626   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 898.5   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 626   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (256)
MICA
Tbio
Novelty:  0.03965901
Score:  0.997
Data Source:  STRINGDB
ULBP3
Tbio
Novelty:  0.0320239
Score:  0.984
Data Source:  STRINGDB
RAET1E
Tbio
Novelty:  0.01859274
Score:  0.963
Data Source:  STRINGDB
MICB
Tbio
Novelty:  0.00364639
Score:  0.96
Data Source:  STRINGDB
RAET1L
Tbio
Novelty:  0.13261616
Score:  0.957
Data Source:  STRINGDB
ULBP2
Tbio
Novelty:  0.01604318
Score:  0.946
Data Source:  STRINGDB
HCST
Tbio
Novelty:  0.01604587
Score:  0.923
Data Source:  Reactome,STRINGDB
IL15
Tbio
Novelty:  0.00049351
Score:  0.921
Data Source:  STRINGDB
NCR1
Tbio
Novelty:  0.00282259
Score:  0.92
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.913
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
DAP12 interactions
Reactome
DAP12 signaling
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
DAP12 interactions
DAP12 signaling
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
92.1
monocyte count
2
2
2
87.2
serum alanine aminotransferase measurement
2
2
1
7
83.6
neutrophil percentage of leukocytes
2
2
2
83.6
mean corpuscular volume
1
1
1
79.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
92.1
monocyte count
2
87.2
serum alanine aminotransferase measurement
1
7
83.6
neutrophil percentage of leukocytes
2
83.6
mean corpuscular volume
1
79.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
killer cell lectin like receptor K1
VGNC:52050
450153
Macaque
NKG2D protein
574240
Mouse
MGI:1196250
27007
Rat
RGD:3180
24934
Dog
killer cell lectin like receptor K1
611355
Species
Name
OMA
EggNOG
Inparanoid
Chimp
killer cell lectin like receptor K1
Macaque
NKG2D protein
Mouse
Rat
Dog
killer cell lectin like receptor K1
Publication Statistics
PubMed Score 898.50
PubMed score by year
PubTator Score 0.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title