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Tbio
KLRC4
NKG2-F type II integral membrane protein

Protein Summary
Description
May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfam ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309384
  • ENSP00000310216
  • ENSG00000183542

Symbol
  • NKG2F
  • NKG2F
  • NKG2-F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
cell type or tissue
0.97
cell line
0.57
gene perturbation
0.48
phenotype
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.72   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.72   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
p_int:  0.999994638
p_ni:  0.000001515
p_wrong:  0.000003847
Data Source:  BioPlex
TMEM62
Tdark
Novelty:  1.79070108
p_int:  0.999993878
p_ni:  0.000006099
p_wrong:  2.3e-8
Data Source:  BioPlex
GSTCD
Tbio
Family:  Enzyme
Novelty:  0.11613228
p_int:  0.9999852
p_ni:  0.000014362
p_wrong:  4.38e-7
Data Source:  BioPlex
SIDT2
Tbio
Novelty:  0.07560652
p_int:  0.999330355
p_ni:  0.000669151
p_wrong:  4.94e-7
Data Source:  BioPlex
SLC22A5
Tbio
Family:  Transporter
Novelty:  0.00290828
p_int:  0.998455219
p_ni:  0.000674368
p_wrong:  0.000870413
Data Source:  BioPlex
PRMT9
Tbio
Family:  Enzyme
Novelty:  0.26898134
p_int:  0.997433409
p_ni:  0.002550309
p_wrong:  0.000016282
Data Source:  BioPlex
OTULIN
Tbio
Family:  Enzyme
Novelty:  0.04694238
p_int:  0.996297577
p_ni:  0.003701235
p_wrong:  0.000001188
Data Source:  BioPlex
MFSD8
Tbio
Novelty:  0.03388459
p_int:  0.994208203
p_ni:  0.005764337
p_wrong:  0.000027461
Data Source:  BioPlex
ALG9
Tbio
Family:  Enzyme
Novelty:  0.02975572
p_int:  0.993467482
p_ni:  0.006532513
p_wrong:  5e-9
Data Source:  BioPlex
TYW1B
Tdark
Family:  Enzyme
Novelty:  0.86504466
p_int:  0.984990977
p_ni:  0.014806072
p_wrong:  0.000202951
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
92.1
monocyte count
2
2
2
87.2
neutrophil percentage of leukocytes
2
2
2
83.6
serum alanine aminotransferase measurement
2
2
1
7
83.6
mean corpuscular volume
1
1
1
79.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
92.1
monocyte count
2
87.2
neutrophil percentage of leukocytes
2
83.6
serum alanine aminotransferase measurement
1
7
83.6
mean corpuscular volume
1
79.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
killer cell lectin-like receptor subfamily C, member 4
450145
Species
Name
OMA
EggNOG
Inparanoid
Chimp
killer cell lectin-like receptor subfamily C, member 4
Publication Statistics
PubMed Score 4.72
PubMed score by year
PubTator Score 5.89
PubTator score by year
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Related Publications
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PMID
Year
Title