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Tchem
KLK8
Kallikrein-8

Protein Summary
Description
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a ge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320838
  • ENSP00000325072
  • ENSG00000129455
  • ENST00000347619
  • ENSP00000341555
  • ENST00000391806
  • ENSP00000375682
  • ENST00000593490
  • ENSP00000469278
  • ENST00000600767
  • ENSP00000472016

Symbol
  • NRPN
  • PRSS19
  • TADG14
  • NP
  • HNP
  • NRPN
  • PRSS19
  • TADG14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
cell type or tissue
0.71
biological process
0.63
protein domain
0.58
chemical
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.26   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 1037   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.26   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 1037   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (15)
CHEMBL4517343
Rendered image for CHEMBL4517343
CHEMBL4558285
Rendered image for CHEMBL4558285
CHEMBL4447752
Rendered image for CHEMBL4447752
CHEMBL4535907
Rendered image for CHEMBL4535907
CHEMBL4543039
Rendered image for CHEMBL4543039
CHEMBL4579813
Rendered image for CHEMBL4579813
CHEMBL4461533
Rendered image for CHEMBL4461533
CHEMBL4465265
Rendered image for CHEMBL4465265
Protein-Protein Interactions (38)
ATP4A
Tclin
Family:  Transporter
Novelty:  0.00008783
p_int:  0.999999194
p_ni:  8.05e-7
p_wrong:  1e-9
Score:  0.287
Data Source:  BioPlex,STRINGDB
RAB39B
Tbio
Family:  Enzyme
Novelty:  0.02362498
p_int:  0.993529364
p_ni:  0.006470636
Score:  0.305
Data Source:  BioPlex,STRINGDB
MT-ND1
Tclin
Family:  Enzyme
Novelty:  0.00090183
p_int:  0.938411272
p_ni:  0.051343529
p_wrong:  0.010245198
Data Source:  BioPlex
ARF5
Tbio
Family:  Enzyme
Novelty:  0.02454098
p_int:  0.936938901
p_ni:  0.063061099
Score:  0.15
Data Source:  BioPlex,STRINGDB
SLC16A10
Tbio
Family:  Transporter
Novelty:  0.02363735
p_int:  0.924589025
p_ni:  0.03354574
p_wrong:  0.041865236
Score:  0.188
Data Source:  BioPlex,STRINGDB
SLC2A8
Tbio
Family:  Transporter
Novelty:  0.02075375
p_int:  0.8647831
p_ni:  0.135199684
p_wrong:  0.000017216
Score:  0.239
Data Source:  BioPlex,STRINGDB
KLK5
Tchem
Family:  Enzyme
Novelty:  0.00835407
Score:  0.957
Data Source:  Reactome,STRINGDB
SPINK9
Tbio
Family:  Enzyme
Novelty:  0.36280131
Score:  0.836
Data Source:  STRINGDB
SERPINA5
Tbio
Family:  Enzyme
Novelty:  0.00152504
Score:  0.756
Data Source:  STRINGDB
SERPINB6
Tbio
Novelty:  0.00568825
Score:  0.755
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
9
12
14
98.3
vitamin D measurement
5
3
5
96.2
kallikrein-11 measurement
1
1
0
1.5
84.6
sialic acid-binding Ig-like lectin 9 measurement
1
2
2
78.9
kallikrein‐6 measurement
1
1
1
77.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
14
98.3
vitamin D measurement
5
96.2
kallikrein-11 measurement
0
1.5
84.6
sialic acid-binding Ig-like lectin 9 measurement
2
78.9
kallikrein‐6 measurement
1
77.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 8
VGNC:11151
456239
Macaque
kallikrein related peptidase 8
719488
Mouse
MGI:1343327
259277
Rat
RGD:1305998
308565
Horse
kallikrein related peptidase 8
VGNC:19489
100067301
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 8
Macaque
kallikrein related peptidase 8
Mouse
Rat
Horse
kallikrein related peptidase 8
Publication Statistics
PubMed Score 157.26
PubMed score by year
PubTator Score 100.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title