Tchem KLK6 Kallikrein-6

Protein Summary

Description

Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q92876
• A6NJA1
• A8MW09
• Q6H301

Gene Name

• KLK6

Ensembl ID

• ENST00000310157
• ENSP00000309148
• ENSG00000167755
• ENST00000376851
• ENSP00000366047
• ENST00000391808
• ENSP00000375684
• ENST00000594641
• ENSP00000470482
• ENST00000597379
• ENSP00000469630
• ENST00000599881
• ENSP00000471948

Symbol

• PRSS18
• PRSS9
• hK6
• Bssp
• Klk7
• SP59
• PRSS9
• PRSS18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.89
cellular component	0.7
PubMedID	0.7
biological term	0.64
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Kallikrein-6

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Kallikrein-6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.29   (req: < 5)

Gene RIFs: 89   (req: <= 3)

Antibodies: 325   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.29   (req: >= 5)

Gene RIFs: 89   (req: > 3)

Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0