Protein Summary
May be involved in desquamation. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
- ENST00000336334
- ENSP00000337733
- ENSG00000167754
- ENST00000391809
- ENSP00000375685
- ENST00000593428
- ENSP00000471966
- SCTE
- SCTE
- KLKL2
- KLK-L2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.66 | ||
small molecule perturbation | 0.61 | ||
cell line | 0.58 | ||
protein domain | 0.58 | ||
biological term | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 158.18 (req: < 5)
Gene RIFs: 58 (req: <= 3)
Antibodies: 326 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 158.18 (req: >= 5)
Gene RIFs: 58 (req: > 3)
Antibodies: 326 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 54
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0