Tchem KLK5 Kallikrein-5

Protein Summary

Description

May be involved in desquamation. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y337
• A0A024R4G4
• Q53ZR3
• Q9HBG8

Gene Name

• KLK5

Ensembl ID

• ENST00000336334
• ENSP00000337733
• ENSG00000167754
• ENST00000391809
• ENSP00000375685
• ENST00000593428
• ENSP00000471966

Symbol

• SCTE
• SCTE
• KLKL2
• KLK-L2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.66
small molecule perturbation	0.61
cell line	0.58
protein domain	0.58
biological term	0.56

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Kallikrein-5

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Kallikrein-5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.62   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 326   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.62   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (54)

Explore Active Ligands

1 – 10 of 54

CHEMBL4517343

KLK5Tchem Enzyme

pIC50 : 8.3

CHEMBL4558285

KLK5Tchem Enzyme

pIC50 : 8.3

SID14731064

KLK5Tchem Enzyme

pIC50 : 7.4

CHEMBL4447752

KLK5Tchem Enzyme

pIC50 : 9.3

compound 4d [PMID: 25489658]

KLK5Tchem Enzyme

pIC50 : 7.19

CHEMBL4535907

KLK5Tchem Enzyme

pIC50 : 8.1

CHEMBL1580091

KLK5Tchem Enzyme

pIC50 : 6.85

CHEMBL4070056

KLK5Tchem Enzyme

pKi : 6.09

CHEMBL4460168

KLK5Tchem Enzyme

pIC50 : 7.6

CHEMBL4543039

KLK5Tchem Enzyme

pIC50 : 8.8

Protein-Protein Interactions (70)

Explore Interacting Targets

1 – 10 of 70

• See Interactions on String-DB

FTH1

Tbio

Novelty:  0.000863

p_int:  0.999922078

p_ni:  0.000031119

p_wrong:  0.000046803

Score:  0.151

Data Source:  BioPlex,STRINGDB

CCND3

Tchem

Novelty:  0.00223085

p_int:  0.999851267

p_ni:  0.00013718

p_wrong:  0.000011553

Data Source:  BioPlex

PI4KA

Tchem

Family:  Kinase

Novelty:  0.01701469

p_int:  0.999335705

p_ni:  0.000664295

Data Source:  BioPlex

FUK

Tbio

Family:  Kinase

Novelty:  0.05169095

p_int:  0.998605781

p_ni:  0.000144463

p_wrong:  0.001249756

Score:  0.187

Data Source:  BioPlex,STRINGDB

POLE2

Tbio

Family:  Enzyme

Novelty:  0.03129531

p_int:  0.988908717

p_ni:  0.006857916

p_wrong:  0.004233367

Data Source:  BioPlex

LOXL2

Tchem

Family:  Enzyme

Novelty:  0.00599536

p_int:  0.987514875

p_ni:  0.01236101

p_wrong:  0.000124115

Data Source:  BioPlex

TUBA4A

Tchem

Novelty:  0.00820546

p_int:  0.986894901

p_ni:  0.013105099

Data Source:  BioPlex

CBWD1

Tbio

Novelty:  0.04321511

p_int:  0.981918993

p_ni:  0.018081007

Data Source:  BioPlex

LCHN

Tdark

Novelty:  0.08678963

p_int:  0.976957538

p_ni:  0.023042462

Score:  0.175

Data Source:  BioPlex,STRINGDB

AP3S1

Tbio

Novelty:  0.12425009

p_int:  0.964793973

p_ni:  0.035205722

p_wrong:  3.05e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

WikiPathways (1)

Developmental Biology (R-HSA-1266738)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Formation of the cornified envelope	75 targets	R-HSA-6809371
Reactome	Keratinization	217 targets	R-HSA-6805567

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Formation of the cornified envelope	75 targets	R-HSA-6809371
Keratinization	217 targets	R-HSA-6805567

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (4)

Components (5)

Processes (6)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
serine-type endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
peptidase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
endopeptidase activity	Traceable Author Statement (TAS)	Reactome
serine-type peptidase activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (9)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
prostate specific antigen measurement	EFO_0004624	7	5	6	39.1	99.2
prostate carcinoma	EFO_0001663	9	6	2	1.2	97.4
vitamin D measurement	EFO_0004631	5	3	5		91.6
blood protein measurement	EFO_0007937	1	2	2		89.8
kallikrein‐6 measurement	EFO_0010622	1	1	1		87.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
prostate specific antigen measurement	EFO_0004624	6	39.1	99.2
prostate carcinoma	EFO_0001663	2	1.2	97.4
vitamin D measurement	EFO_0004631	5		91.6
blood protein measurement	EFO_0007937	2		89.8
kallikrein‐6 measurement	EFO_0010622	1		87.2

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UniProt Keyword Find Similar Targets

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3D-structure
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Polymorphism
Protease
Reference proteome
Secreted
Serine protease

GWAS Trait Find Similar Targets

No Header	No Header
blood protein measurement
cancer
cancer aggressiveness measurement
Gleason score measurement
kallikrein-11 measurement
kallikrein‐6 measurement
prostate carcinoma
prostate specific antigen measurement
vitamin D measurement

MGI Phenotype Find Similar Targets

No Header	No Header
limbs/digits/tail phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	kallikrein related peptidase 5	VGNC:2327	748162
Macaque	kallikrein related peptidase 5		719467
Mouse	kallikrein related-peptidase 5	MGI:1915918	68668
Dog	kallikrein related peptidase 5	VGNC:42483	484353
Horse	kallikrein related peptidase 5 [Source:HGNC Symbol;Acc:HGNC:6366]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	kallikrein related peptidase 5
Macaque	kallikrein related peptidase 5
Mouse	kallikrein related-peptidase 5
Dog	kallikrein related peptidase 5
Horse	kallikrein related peptidase 5 [Source:HGNC Symbol;Acc:HGNC:6366]

Publication Statistics

PubMed Score 136.62

PubMed score by year

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PubTator Score 84.68

PubTator score by year

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Related Publications

Text Mined References (61)

GeneRif Annotations (45)

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10

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PMID	Year	Title