Protein Summary
May be involved in desquamation. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
- ENST00000336334
- ENSP00000337733
- ENSG00000167754
- ENST00000391809
- ENSP00000375685
- ENST00000593428
- ENSP00000471966
- SCTE
- SCTE
- KLKL2
- KLK-L2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.66 | ||
small molecule perturbation | 0.61 | ||
cell line | 0.58 | ||
protein domain | 0.58 | ||
biological term | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 158.18 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 326 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 158.18 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 326 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 54
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (54)
Protein-Protein Interactions (70)
FTH1
Novelty: 0.000863
p_int: 0.999922078
p_ni: 0.000031119
p_wrong: 0.000046803
Score: 0.151
Data Source: BioPlex,STRINGDB
CCND3
Novelty: 0.00223085
p_int: 0.999851267
p_ni: 0.00013718
p_wrong: 0.000011553
Data Source: BioPlex
PI4KA
Family: Kinase
Novelty: 0.01701469
p_int: 0.999335705
p_ni: 0.000664295
Data Source: BioPlex
FUK
Family: Kinase
Novelty: 0.05169095
p_int: 0.998605781
p_ni: 0.000144463
p_wrong: 0.001249756
Score: 0.187
Data Source: BioPlex,STRINGDB
POLE2
Family: Enzyme
Novelty: 0.03129531
p_int: 0.988908717
p_ni: 0.006857916
p_wrong: 0.004233367
Data Source: BioPlex
LOXL2
Family: Enzyme
Novelty: 0.00599536
p_int: 0.987514875
p_ni: 0.01236101
p_wrong: 0.000124115
Data Source: BioPlex
LCHN
Novelty: 0.08678963
p_int: 0.976957538
p_ni: 0.023042462
Score: 0.175
Data Source: BioPlex,STRINGDB
AP3S1
Novelty: 0.12425009
p_int: 0.964793973
p_ni: 0.035205722
p_wrong: 3.05e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (4)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
prostate specific antigen measurement | 7 | 5 | 6 | 39.1 | 99.7 | ||||
9 | 6 | 2 | 1.2 | 99.3 | |||||
blood protein measurement | 7 | 9 | 10 | 98.2 | |||||
vitamin D measurement | 5 | 3 | 5 | 96.2 | |||||
kallikrein-11 measurement | 1 | 1 | 0 | 1.5 | 84.6 | ||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
prostate specific antigen measurement | 6 | 39.1 | 99.7 | ||||
2 | 1.2 | 99.3 | |||||
blood protein measurement | 10 | 98.2 | |||||
vitamin D measurement | 5 | 96.2 | |||||
kallikrein-11 measurement | 0 | 1.5 | 84.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | kallikrein related peptidase 5 | VGNC:2327 | 748162 | |||||
Macaque | kallikrein related peptidase 5 | 719467 | ||||||
Mouse | MGI:1915918 | 68668 | ||||||
Dog | kallikrein related peptidase 5 | VGNC:42483 | 484353 | |||||
Horse | kallikrein related peptidase 5 [Source:HGNC Symbol;Acc:HGNC:6366] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | kallikrein related peptidase 5 | |||||
Macaque | kallikrein related peptidase 5 | |||||
Mouse | ||||||
Dog | kallikrein related peptidase 5 | |||||
Horse | kallikrein related peptidase 5 [Source:HGNC Symbol;Acc:HGNC:6366] | |||||
Publication Statistics
PubMed Score 158.18
PubMed score by year
PubTator Score 84.68
PubTator score by year
Related Publications
Text Mined References (61)
GeneRif Annotations (45)
Items per page:
0 of 0
PMID | Year | Title |
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