You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
KLK5
Kallikrein-5

Protein Summary
Description
May be involved in desquamation. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336334
  • ENSP00000337733
  • ENSG00000167754
  • ENST00000391809
  • ENSP00000375685
  • ENST00000593428
  • ENSP00000471966

Symbol
  • SCTE
  • SCTE
  • KLKL2
  • KLK-L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.66
small molecule perturbation
0.61
cell line
0.58
protein domain
0.58
biological term
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.62   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.62   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (70)
FTH1
Tbio
Novelty:  0.000863
p_int:  0.999922078
p_ni:  0.000031119
p_wrong:  0.000046803
Score:  0.151
Data Source:  BioPlex,STRINGDB
CCND3
Tchem
Novelty:  0.00223085
p_int:  0.999851267
p_ni:  0.00013718
p_wrong:  0.000011553
Data Source:  BioPlex
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.999335705
p_ni:  0.000664295
Data Source:  BioPlex
FUK
Tbio
Family:  Kinase
Novelty:  0.05169095
p_int:  0.998605781
p_ni:  0.000144463
p_wrong:  0.001249756
Score:  0.187
Data Source:  BioPlex,STRINGDB
POLE2
Tbio
Family:  Enzyme
Novelty:  0.03129531
p_int:  0.988908717
p_ni:  0.006857916
p_wrong:  0.004233367
Data Source:  BioPlex
LOXL2
Tchem
Family:  Enzyme
Novelty:  0.00599536
p_int:  0.987514875
p_ni:  0.01236101
p_wrong:  0.000124115
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.986894901
p_ni:  0.013105099
Data Source:  BioPlex
CBWD1
Tbio
Novelty:  0.04321511
p_int:  0.981918993
p_ni:  0.018081007
Data Source:  BioPlex
LCHN
Tdark
Novelty:  0.08678963
p_int:  0.976957538
p_ni:  0.023042462
Score:  0.175
Data Source:  BioPlex,STRINGDB
AP3S1
Tbio
Novelty:  0.12425009
p_int:  0.964793973
p_ni:  0.035205722
p_wrong:  3.05e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
7
5
6
39.1
99.2
9
6
2
1.2
97.4
vitamin D measurement
5
3
5
91.6
blood protein measurement
1
2
2
89.8
kallikrein‐6 measurement
1
1
1
87.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
6
39.1
99.2
2
1.2
97.4
vitamin D measurement
5
91.6
blood protein measurement
2
89.8
kallikrein‐6 measurement
1
87.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 5
VGNC:2327
748162
Macaque
kallikrein related peptidase 5
719467
Mouse
MGI:1915918
68668
Dog
kallikrein related peptidase 5
VGNC:42483
484353
Horse
kallikrein related peptidase 5 [Source:HGNC Symbol;Acc:HGNC:6366]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 5
Macaque
kallikrein related peptidase 5
Mouse
Dog
kallikrein related peptidase 5
Horse
kallikrein related peptidase 5 [Source:HGNC Symbol;Acc:HGNC:6366]
Publication Statistics
PubMed Score 136.62
PubMed score by year
PubTator Score 84.68
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title