Protein Summary
Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity). Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014]
- ENST00000431178
- ENSP00000399448
- ENSG00000167749
- EMSP1
- PRSS17
- PSTS
- ARM1
- EMSP
- PSTS
- AI2A1
- EMSP1
- KLK-L1
- PRSS17
- kallikrein
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.78 | ||
cell type or tissue | 0.65 | ||
protein domain | 0.58 | ||
biological term | 0.54 | ||
cell line | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4958.69 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 265 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4958.69 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 265 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 15
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (15)
Protein-Protein Interactions (92)
HLA-DRA
Novelty: 0.0060214
p_int: 0.999486575
p_ni: 0.000016976
p_wrong: 0.000496449
Score: 0.806
Data Source: BioPlex,STRINGDB
KCNIP4
Family: IC
Novelty: 0.00973829
p_int: 0.801663715
p_ni: 0.19833593
p_wrong: 3.55e-7
Score: 0.855
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
PathwayCommons (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: pid | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (3)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
prostate specific antigen measurement | 8 | 6 | 7 | 39.1 | 99.4 | ||||
9 | 7 | 2 | 1.2 | 97.6 | |||||
kallikreinâ6 measurement | 1 | 1 | 1 | 87.2 | |||||
1 | 2 | 0 | 1.3 | 84 | |||||
blood protein measurement | 1 | 1 | 1 | 30.1 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
prostate specific antigen measurement | 7 | 39.1 | 99.4 | ||||
2 | 1.2 | 97.6 | |||||
kallikreinâ6 measurement | 1 | 87.2 | |||||
0 | 1.3 | 84 | |||||
blood protein measurement | 1 | 30.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | kallikrein related peptidase 4 | VGNC:2328 | 469101 | |||||
Mouse | MGI:1861379 | 56640 | ||||||
Rat | RGD:1303228 | 408210 | ||||||
Dog | kallikrein related peptidase 4 | VGNC:42482 | 484354 | |||||
Horse | kallikrein-4-like | 100067485 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | kallikrein related peptidase 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | kallikrein related peptidase 4 | |||||
Horse | kallikrein-4-like | |||||
Publication Statistics
PubMed Score 4958.69
PubMed score by year
PubTator Score 1420.88
PubTator score by year
Related Publications
Text Mined References (75)
GeneRif Annotations (51)
Items per page:
0 of 0
PMID | Year | Title |
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