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Tchem
KLK4
Kallikrein-4

Protein Summary
Description
Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity). Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431178
  • ENSP00000399448
  • ENSG00000167749

Symbol
  • EMSP1
  • PRSS17
  • PSTS
  • ARM1
  • EMSP
  • PSTS
  • AI2A1
  • EMSP1
  • KLK-L1
  • PRSS17
  • kallikrein
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
cell type or tissue
0.65
protein domain
0.58
biological term
0.54
cell line
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4958.69   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4958.69   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (15)
Protein-Protein Interactions (92)
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.999486575
p_ni:  0.000016976
p_wrong:  0.000496449
Score:  0.806
Data Source:  BioPlex,STRINGDB
KCNIP4
Tbio
Family:  IC
Novelty:  0.00973829
p_int:  0.801663715
p_ni:  0.19833593
p_wrong:  3.55e-7
Score:  0.855
Data Source:  BioPlex,STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
Score:  0.946
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.922
Data Source:  STRINGDB
SERPING1
Tbio
Family:  Enzyme
Novelty:  0.00068448
Score:  0.865
Data Source:  STRINGDB
MMP20
Tbio
Family:  Enzyme
Novelty:  0.00925618
Score:  0.844
Data Source:  STRINGDB
ENAM
Tbio
Novelty:  0.00593293
Score:  0.841
Data Source:  STRINGDB
REN
Tclin
Family:  Enzyme
Novelty:  0.00002435
Score:  0.838
Data Source:  STRINGDB
AMBN
Tbio
Novelty:  0.00354946
Score:  0.814
Data Source:  STRINGDB
AMELX
Tbio
Novelty:  0.00063284
Score:  0.803
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
8
6
7
39.1
99.4
9
7
2
1.2
97.6
kallikrein‐6 measurement
1
1
1
87.2
1
2
0
1.3
84
blood protein measurement
1
1
1
30.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
7
39.1
99.4
2
1.2
97.6
kallikrein‐6 measurement
1
87.2
0
1.3
84
blood protein measurement
1
30.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 4
VGNC:2328
469101
Mouse
MGI:1861379
56640
Rat
RGD:1303228
408210
Dog
kallikrein related peptidase 4
VGNC:42482
484354
Horse
kallikrein-4-like
100067485
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 4
Mouse
Rat
Dog
kallikrein related peptidase 4
Horse
kallikrein-4-like
Publication Statistics
PubMed Score 4958.69
PubMed score by year
PubTator Score 1420.88
PubTator score by year
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Related Publications
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PMID
Year
Title