Protein Summary
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000326003
- ENSP00000314151
- ENSG00000142515
- ENST00000360617
- ENSP00000353829
- ENST00000593997
- ENSP00000472907
- ENST00000595952
- ENSP00000471155
- APS
- APS
- PSA
- hK3
- KLK2A1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
transcription factor perturbation | 0.97 | ||
chemical | 0.94 | ||
PubMedID | 0.94 | ||
disease | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27096.27 (req: < 5)
Gene RIFs: 322 (req: <= 3)
Antibodies: 2256 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27096.27 (req: >= 5)
Gene RIFs: 322 (req: > 3)
Antibodies: 2256 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 25
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (25)
Protein-Protein Interactions (179)
UBA52
Novelty: 0.01637744
p_int: 0.999934313
p_ni: 0.000065654
p_wrong: 3.3e-8
Score: 0.537
Data Source: BioPlex,STRINGDB
MIF4GD
Novelty: 0.04798623
p_int: 0.999631086
p_ni: 0.000058941
p_wrong: 0.000309973
Score: 0.54
Data Source: BioPlex,STRINGDB
ITPA
Family: Enzyme
Novelty: 0.00235169
p_int: 0.977555227
p_ni: 0.017862843
p_wrong: 0.004581931
Data Source: BioPlex
GRN
Novelty: 0.00096395
p_int: 0.947454277
p_ni: 0.052533553
p_wrong: 0.00001217
Data Source: BioPlex
HSPA5
Novelty: 0.00043424
p_int: 0.841115229
p_ni: 0.158884771
Score: 0.296
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (37)
Reactome (7)
KEGG (2)
PathwayCommons (5)
WikiPathways (23)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Reactome | Metabolism of proteins | ||||
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases activate PKNs | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
Metabolism of proteins | ||||
RHO GTPase Effectors | ||||
RHO GTPases activate PKNs | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (4)
Components (6)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
prostate specific antigen measurement | 8 | 6 | 7 | 39.1 | 99.4 | ||||
9 | 7 | 2 | 1.2 | 97.6 | |||||
1 | 2 | 0 | 1.3 | 84 | |||||
Gleason score measurement | 1 | 1 | 1 | 28.1 | |||||
cancer aggressiveness measurement | 1 | 1 | 1 | 28.1 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
prostate specific antigen measurement | 7 | 39.1 | 99.4 | ||||
2 | 1.2 | 97.6 | |||||
0 | 1.3 | 84 | |||||
Gleason score measurement | 1 | 28.1 | |||||
cancer aggressiveness measurement | 1 | 28.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | kallikrein related peptidase 3 | VGNC:11150 | 493182 | |||||
Macaque | kallikrein 3 | 719444 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | kallikrein related peptidase 3 | |||||
Macaque | kallikrein 3 | |||||
Publication Statistics
PubMed Score 27096.27
PubMed score by year
PubTator Score 17542.90
PubTator score by year
Related Publications
Text Mined References (414)
GeneRif Annotations (322)
Items per page:
0 of 0
PMID | Year | Title |
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