Protein Summary
Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate t ...more
- ENST00000391802
- ENSP00000375678
- ENSG00000129437
- KLKL6
- KLK-L6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.58 | ||
biological term | 0.51 | ||
cell line | 0.49 | ||
trait | 0.46 | ||
cell type or tissue | 0.44 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.54 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 193 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.54 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 193 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 17
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (17)
Protein-Protein Interactions (27)
GTPBP3
Family: Enzyme
Novelty: 0.08129502
p_int: 0.874260627
p_ni: 0.125739373
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 5 | 3 | 5 | 91.6 | |||||
blood protein measurement | 1 | 1 | 1 | 86.5 | |||||
kallikrein-11 measurement | 1 | 1 | 0 | 1.5 | 69.5 | ||||
C-reactive protein measurement | 1 | 1 | 1 | 38.8 | |||||
monocyte percentage of leukocytes | 2 | 1 | 2 | 37.5 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 5 | 91.6 | |||||
blood protein measurement | 1 | 86.5 | |||||
kallikrein-11 measurement | 0 | 1.5 | 69.5 | ||||
C-reactive protein measurement | 1 | 38.8 | |||||
monocyte percentage of leukocytes | 2 | 37.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2447564 | 317653 | ||||||
Rat | RGD:1308606 | 308562 | ||||||
Dog | kallikrein related peptidase 14 | VGNC:42481 | 484348 | |||||
Horse | kallikrein related peptidase 14 | VGNC:19486 | 100067040 | |||||
Cow | kallikrein related peptidase 14 | VGNC:30676 | 613993 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | kallikrein related peptidase 14 | |||||
Horse | kallikrein related peptidase 14 | |||||
Cow | kallikrein related peptidase 14 | |||||
Publication Statistics
PubMed Score 50.54
PubMed score by year
PubTator Score 33.15
PubTator score by year
Related Publications
Text Mined References (37)
GeneRif Annotations (26)
Items per page:
0 of 0
PMID | Year | Title |
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