You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
KLK14
Kallikrein-14

Protein Summary
Description
Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391802
  • ENSP00000375678
  • ENSG00000129437

Symbol
  • KLKL6
  • KLK-L6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
biological term
0.51
cell line
0.49
trait
0.46
cell type or tissue
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.54   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.54   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (17)
CHEMBL4517343
Rendered image for CHEMBL4517343
CHEMBL4558285
Rendered image for CHEMBL4558285
SID14731064
Rendered image for SID14731064
CHEMBL4447752
Rendered image for CHEMBL4447752
compound 4d [PMID: 25489658]
Rendered image for compound 4d [PMID: 25489658]
CHEMBL1580091
Rendered image for CHEMBL1580091
CHEMBL4460168
Rendered image for CHEMBL4460168
CHEMBL4543039
Rendered image for CHEMBL4543039
CHEMBL4579813
Rendered image for CHEMBL4579813
CHEMBL4461533
Rendered image for CHEMBL4461533
Protein-Protein Interactions (27)
GTPBP3
Tbio
Family:  Enzyme
Novelty:  0.08129502
p_int:  0.874260627
p_ni:  0.125739373
Data Source:  BioPlex
CNNM4
Tbio
Novelty:  0.04199329
p_int:  0.787563763
p_ni:  0.212436237
Data Source:  BioPlex
SPINK6
Tbio
Family:  Enzyme
Novelty:  0.11687263
Score:  0.968
Data Source:  Reactome,STRINGDB
SPINK5
Tbio
Family:  Enzyme
Novelty:  0.00451563
Score:  0.836
Data Source:  STRINGDB
SIGLEC9
Tbio
Novelty:  0.01805735
Score:  0.8
Data Source:  STRINGDB
CDSN
Tbio
Novelty:  0.01118491
Score:  0.677
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.668
Data Source:  STRINGDB
SIGLEC7
Tchem
Novelty:  0.01496432
Score:  0.648
Data Source:  STRINGDB
TGM4
Tbio
Family:  Enzyme
Novelty:  0.01478178
Score:  0.641
Data Source:  STRINGDB
SPINK9
Tbio
Family:  Enzyme
Novelty:  0.36280131
Score:  0.569
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
3
5
91.6
blood protein measurement
1
1
1
86.5
kallikrein-11 measurement
1
1
0
1.5
69.5
C-reactive protein measurement
1
1
1
38.8
monocyte percentage of leukocytes
2
1
2
37.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
91.6
blood protein measurement
1
86.5
kallikrein-11 measurement
0
1.5
69.5
C-reactive protein measurement
1
38.8
monocyte percentage of leukocytes
2
37.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2447564
317653
Rat
RGD:1308606
308562
Dog
kallikrein related peptidase 14
VGNC:42481
484348
Horse
kallikrein related peptidase 14
VGNC:19486
100067040
Cow
kallikrein related peptidase 14
VGNC:30676
613993
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
kallikrein related peptidase 14
Horse
kallikrein related peptidase 14
Cow
kallikrein related peptidase 14
Publication Statistics
PubMed Score 50.54
PubMed score by year
PubTator Score 33.15
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title