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Tbio
KLHL9
Kelch-like protein 9

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. This gene encodes a protein that belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain, a BACK domain and six C-terminal kelch repeats. The encoded protein is a component of a complex with cullin 3-based E3 ligase, which plays a role in mitosis. This protein complex is a cell cycle regulator, and functions in the organization and integrity of the spindle midzone in anaphase and the completion of cytokinesis. The complex is required for the removal of the chromosomal passenger protein aurora B from mitotic chromosomes. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359039
  • ENSP00000351933
  • ENSG00000198642

Symbol
  • KIAA1354
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
protein domain
0.92
transcription factor perturbation
0.84
virus perturbation
0.79
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.28   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.28   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (323)
ATP1A4
Tclin
Family:  Transporter
Novelty:  0.01011201
p_int:  0.999997517
p_ni:  0.000002256
p_wrong:  2.27e-7
Data Source:  BioPlex
IPP
Tbio
Novelty:  0.12841634
p_int:  0.999987207
p_ni:  0.000012792
p_wrong:  1e-9
Data Source:  BioPlex
FBXL17
Tbio
Novelty:  0.16122137
p_int:  0.999977773
p_ni:  0.00002222
p_wrong:  7e-9
Data Source:  BioPlex
BACH2
Tbio
Family:  TF
Novelty:  0.00932069
p_int:  0.999847637
p_ni:  0.000149665
p_wrong:  0.000002698
Score:  0.192
Data Source:  BioPlex,STRINGDB
NUDCD3
Tbio
Novelty:  0.32026811
p_int:  0.999667429
p_ni:  0.000332571
Data Source:  BioPlex
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.999632738
p_ni:  0.000367262
Data Source:  BioPlex
MYH7
Tclin
Novelty:  0.00268092
p_int:  0.997594986
p_ni:  0.00240063
p_wrong:  0.000004384
Data Source:  BioPlex
KLHL26
Tdark
Novelty:  1.53240393
p_int:  0.995821149
p_ni:  0.004178851
Data Source:  BioPlex
KLHL24
Tbio
Novelty:  0.04032749
p_int:  0.982254679
p_ni:  0.01774532
Data Source:  BioPlex
KLHL13
Tdark
Novelty:  0.23576387
p_int:  0.955507154
p_ni:  0.044492846
Score:  0.953
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
10.7
11.2
maculopapular eruption
1
1
0
10.7
11.2
response to lamotrigine
1
1
0
10.7
11.2
neutrophil count
3
1
3
8.5
lymphocyte percentage of leukocytes
1
1
1
8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
10.7
11.2
maculopapular eruption
0
10.7
11.2
response to lamotrigine
0
10.7
11.2
neutrophil count
3
8.5
lymphocyte percentage of leukocytes
1
8
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 9
VGNC:13904
465018
Mouse
MGI:2180122
242521
Rat
RGD:1304814
313348
Cow
kelch like family member 9
VGNC:30671
767834
Pig
kelch like family member 9
100739402
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 9
Mouse
Rat
Cow
kelch like family member 9
Pig
kelch like family member 9
Publication Statistics
PubMed Score 5.28
PubMed score by year
PubTator Score 2.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title