Tdark KLHL8 Kelch-like protein 8

Protein Summary

Description

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Uniprot Accession IDs

• Q9P2G9
• Q53XA3
• Q6N018

Gene Name

• KLHL8

Ensembl ID

• ENST00000273963
• ENSP00000273963
• ENSG00000145332
• ENST00000498875
• ENSP00000426451
• ENST00000512111
• ENSP00000424131

Symbol

• KIAA1378

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
histone modification site profile	0.8
kinase perturbation	0.76
transcription factor binding site profile	0.66
microRNA	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.66   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.66   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (60)

Explore Interacting Targets

1 – 10 of 60

• See Interactions on String-DB

CUL3

Tbio

Novelty:  0.0028737

p_int:  0.999999523

p_ni:  4.76e-7

p_wrong:  1e-9

Score:  0.79

Data Source:  BioPlex,STRINGDB

CCT2

Tbio

Novelty:  0.01967139

p_int:  0.999829596

p_ni:  0.000170403

Data Source:  BioPlex

SNRNP70

Tbio

Novelty:  0.00116631

p_int:  0.99980076

p_ni:  0.00019924

Data Source:  BioPlex

CCT5

Tbio

Novelty:  0.02369118

p_int:  0.999756228

p_ni:  0.000243469

p_wrong:  3.03e-7

Data Source:  BioPlex

TCEAL5

Tdark

Novelty:  1.78893063

p_int:  0.998882039

p_ni:  0.001116728

p_wrong:  0.000001233

Data Source:  BioPlex

RACGAP1

Tbio

Family:  Enzyme

Novelty:  0.01197099

p_int:  0.998501468

p_ni:  0.001498454

p_wrong:  7.9e-8

Data Source:  BioPlex

TAF15

Tbio

Novelty:  0.0621505

p_int:  0.998216355

p_ni:  0.001783596

p_wrong:  4.9e-8

Score:  0.206

Data Source:  BioPlex,STRINGDB

CCDC120

Tbio

Novelty:  0.48574876

p_int:  0.99773354

p_ni:  0.002266457

p_wrong:  3e-9

Data Source:  BioPlex

GEMIN8

Tbio

Novelty:  0.19515325

p_int:  0.997360048

p_ni:  0.002619829

p_wrong:  0.000020123

Score:  0.558

Data Source:  BioPlex,STRINGDB

DPYSL4

Tbio

Family:  Enzyme

Novelty:  0.0449179

p_int:  0.996721106

p_ni:  0.003262091

p_wrong:  0.000016803

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

UniProt (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
UniProt	Protein modification; protein ubiquitination.	399 targets

Name	Explore in Pharos	Explore in Source
Protein modification; protein ubiquitination.	399 targets

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Components (2)

Processes (2)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
Cul3-RING ubiquitin ligase complex	Inferred from Direct Assay (IDA)	UniProtKB
nucleoplasm	Inferred from Direct Assay (IDA)	HPA

Disease Associations ()

No disease associations found

GWAS Traits (27)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 27

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	18	14	26	2.3	98.8
serum alanine aminotransferase measurement	EFO_0004735	5	5	4	10.1	98.2
hemoglobin measurement	EFO_0004509	5	4	5		97.4
hematocrit	EFO_0004348	5	4	5		97.2
aspartate aminotransferase measurement	EFO_0004736	4	4	4	16	96.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 27

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	26	2.3	98.8
serum alanine aminotransferase measurement	EFO_0004735	4	10.1	98.2
hemoglobin measurement	EFO_0004509	5		97.4
hematocrit	EFO_0004348	5		97.2
aspartate aminotransferase measurement	EFO_0004736	4	16	96.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Kelch repeat
Polymorphism
Reference proteome
Repeat
Ubl conjugation pathway

GWAS Trait Find Similar Targets

No Header	No Header
alcoholic liver cirrhosis
aspartate aminotransferase measurement
basophil count
basophil percentage of leukocytes
bilirubin measurement
erythrocyte count
heel bone mineral density
hematocrit
hemoglobin measurement
high density lipoprotein cholesterol measurement

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	kelch like family member 8	VGNC:2981	461363
Macaque	kelch like family member 8		700864
Mouse	kelch-like 8	MGI:2179430	246293
Rat	kelch-like family member 8	RGD:1304685	289457
Dog	kelch like family member 8	VGNC:42477	487847

Species	Name	OMA	EggNOG	Inparanoid
Chimp	kelch like family member 8
Macaque	kelch like family member 8
Mouse	kelch-like 8
Rat	kelch-like family member 8
Dog	kelch like family member 8

Publication Statistics

PubMed Score 2.66

PubMed score by year

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PubTator Score 0.70

PubTator score by year

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Related Publications

Text Mined References (16)

GeneRif Annotations (1)

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10

0 of 0

PMID	Year	Title