Protein Summary
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.
- ENST00000273963
- ENSP00000273963
- ENSG00000145332
- ENST00000498875
- ENSP00000426451
- ENST00000512111
- ENSP00000424131
- KIAA1378
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.97 | ||
histone modification site profile | 0.8 | ||
kinase perturbation | 0.76 | ||
transcription factor binding site profile | 0.66 | ||
microRNA | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.66 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 90 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.66 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 90 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (60)
CUL3
Novelty: 0.0028737
p_int: 0.999999523
p_ni: 4.76e-7
p_wrong: 1e-9
Score: 0.79
Data Source: BioPlex,STRINGDB
CCT5
Novelty: 0.02369118
p_int: 0.999756228
p_ni: 0.000243469
p_wrong: 3.03e-7
Data Source: BioPlex
TCEAL5
Novelty: 1.78893063
p_int: 0.998882039
p_ni: 0.001116728
p_wrong: 0.000001233
Data Source: BioPlex
RACGAP1
Family: Enzyme
Novelty: 0.01197099
p_int: 0.998501468
p_ni: 0.001498454
p_wrong: 7.9e-8
Data Source: BioPlex
TAF15
Novelty: 0.0621505
p_int: 0.998216355
p_ni: 0.001783596
p_wrong: 4.9e-8
Score: 0.206
Data Source: BioPlex,STRINGDB
CCDC120
Novelty: 0.48574876
p_int: 0.99773354
p_ni: 0.002266457
p_wrong: 3e-9
Data Source: BioPlex
GEMIN8
Novelty: 0.19515325
p_int: 0.997360048
p_ni: 0.002619829
p_wrong: 0.000020123
Score: 0.558
Data Source: BioPlex,STRINGDB
DPYSL4
Family: Enzyme
Novelty: 0.0449179
p_int: 0.996721106
p_ni: 0.003262091
p_wrong: 0.000016803
Data Source: BioPlex
Nearest Tclin Targets
Pathways (1)
UniProt (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
UniProt | Protein modification; protein ubiquitination. | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Protein modification; protein ubiquitination. | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Disease Associations ()
GWAS Traits (27)
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 18 | 14 | 26 | 2.3 | 98.8 | ||||
serum alanine aminotransferase measurement | 5 | 5 | 4 | 10.1 | 98.2 | ||||
hemoglobin measurement | 5 | 4 | 5 | 97.4 | |||||
hematocrit | 5 | 4 | 5 | 97.2 | |||||
aspartate aminotransferase measurement | 4 | 4 | 4 | 16 | 96.4 | ||||
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
triglyceride measurement | 26 | 2.3 | 98.8 | ||||
serum alanine aminotransferase measurement | 4 | 10.1 | 98.2 | ||||
hemoglobin measurement | 5 | 97.4 | |||||
hematocrit | 5 | 97.2 | |||||
aspartate aminotransferase measurement | 4 | 16 | 96.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | kelch like family member 8 | VGNC:2981 | 461363 | |||||
Macaque | kelch like family member 8 | 700864 | ||||||
Mouse | MGI:2179430 | 246293 | ||||||
Rat | RGD:1304685 | 289457 | ||||||
Dog | kelch like family member 8 | VGNC:42477 | 487847 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | kelch like family member 8 | |||||
Macaque | kelch like family member 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | kelch like family member 8 | |||||
Publication Statistics
PubMed Score 2.66
PubMed score by year
PubTator Score 0.70
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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