Tdark KLHL8 Kelch-like protein 8

Protein Summary

Description

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Uniprot Accession IDs

• Q9P2G9
• Q53XA3
• Q6N018

Gene Name

• KLHL8

Ensembl ID

• ENST00000273963
• ENSP00000273963
• ENSG00000145332
• ENST00000498875
• ENSP00000426451
• ENST00000512111
• ENSP00000424131

Symbol

• KIAA1378

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
histone modification site profile	0.8
kinase perturbation	0.76
transcription factor binding site profile	0.66
microRNA	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.78   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.78   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0