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Tdark
KLHL8
Kelch-like protein 8

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273963
  • ENSP00000273963
  • ENSG00000145332
  • ENST00000498875
  • ENSP00000426451
  • ENST00000512111
  • ENSP00000424131

Symbol
  • KIAA1378
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
histone modification site profile
0.8
kinase perturbation
0.76
transcription factor binding site profile
0.66
microRNA
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.66   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.66   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999999523
p_ni:  4.76e-7
p_wrong:  1e-9
Score:  0.79
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999829596
p_ni:  0.000170403
Data Source:  BioPlex
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.99980076
p_ni:  0.00019924
Data Source:  BioPlex
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.999756228
p_ni:  0.000243469
p_wrong:  3.03e-7
Data Source:  BioPlex
TCEAL5
Tdark
Novelty:  1.78893063
p_int:  0.998882039
p_ni:  0.001116728
p_wrong:  0.000001233
Data Source:  BioPlex
RACGAP1
Tbio
Family:  Enzyme
Novelty:  0.01197099
p_int:  0.998501468
p_ni:  0.001498454
p_wrong:  7.9e-8
Data Source:  BioPlex
TAF15
Tbio
Novelty:  0.0621505
p_int:  0.998216355
p_ni:  0.001783596
p_wrong:  4.9e-8
Score:  0.206
Data Source:  BioPlex,STRINGDB
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.99773354
p_ni:  0.002266457
p_wrong:  3e-9
Data Source:  BioPlex
GEMIN8
Tbio
Novelty:  0.19515325
p_int:  0.997360048
p_ni:  0.002619829
p_wrong:  0.000020123
Score:  0.558
Data Source:  BioPlex,STRINGDB
DPYSL4
Tbio
Family:  Enzyme
Novelty:  0.0449179
p_int:  0.996721106
p_ni:  0.003262091
p_wrong:  0.000016803
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
18
14
26
2.3
98.8
serum alanine aminotransferase measurement
5
5
4
10.1
98.2
hemoglobin measurement
5
4
5
97.4
hematocrit
5
4
5
97.2
aspartate aminotransferase measurement
4
4
4
16
96.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
26
2.3
98.8
serum alanine aminotransferase measurement
4
10.1
98.2
hemoglobin measurement
5
97.4
hematocrit
5
97.2
aspartate aminotransferase measurement
4
16
96.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 8
VGNC:2981
461363
Macaque
kelch like family member 8
700864
Mouse
MGI:2179430
246293
Rat
RGD:1304685
289457
Dog
kelch like family member 8
VGNC:42477
487847
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 8
Macaque
kelch like family member 8
Mouse
Rat
Dog
kelch like family member 8
Publication Statistics
PubMed Score 2.66
PubMed score by year
PubTator Score 0.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title